Han Chuanliang, Zhao Xixi, Li Meijia, Haihambo Naem, Teng Jiayi, Li Sixiao, Qiu Jinyi, Feng Xiaoyang, Gao Michel
Shenzhen Key Laboratory of Neuropsychiatric Modulation and Collaborative Innovation Center for Brain Science, Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Center for Excellence in Brain Science and Intelligence Technology, Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Fundamental Research Institutions, Shenzhen, 518055 China.
The National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088 China.
Cogn Neurodyn. 2023 Apr;17(2):399-410. doi: 10.1007/s11571-022-09834-x. Epub 2022 Jul 7.
Gamma-band activity was thought to be related to several high-level cognitive functions, and Gamma ENtrainment Using Sensory stimulation (GENUS, 40 Hz sensory combined visual and auditory stimulation) was found to have positive effects on patients with Alzheimer's dementia. Other studies found, however, that neural responses induced by single 40 Hz auditory stimulation were relatively weak. To address this, we included several new experimental conditions (sounds with sinusoidal or square wave; open-eye and closed-eye state) combined with auditory stimulation with the aim of investigating which of these induces a stronger 40 Hz neural response. We found that when participant´s eyes were closed, sounds with 40 Hz sinusoidal wave induced the strongest 40 Hz neural response in the prefrontal region compared to responses in other conditions. More interestingly, we also found there is a suppression of alpha rhythms with 40 Hz square wave sounds. Our results provide potential new methods when using auditory entrainment, which may result in a better effect in preventing cerebral atrophy and improving cognitive performance.
The online version contains supplementary material available at 10.1007/s11571-022-09834-x.
伽马波段活动被认为与多种高级认知功能有关，并且发现使用感觉刺激的伽马诱导（GENUS，40赫兹感觉联合视觉和听觉刺激）对阿尔茨海默病痴呆患者有积极影响。然而，其他研究发现，单次40赫兹听觉刺激诱发的神经反应相对较弱。为了解决这个问题，我们纳入了几种新的实验条件（正弦波或方波声音；睁眼和闭眼状态）并结合听觉刺激，目的是研究其中哪种能诱发更强的40赫兹神经反应。我们发现，当参与者闭眼时，与其他条件下的反应相比，40赫兹正弦波声音在前额叶区域诱发的40赫兹神经反应最强。更有趣的是，我们还发现40赫兹方波声音会抑制阿尔法节律。我们的结果为使用听觉诱导提供了潜在的新方法，这可能在预防脑萎缩和改善认知表现方面产生更好的效果。
在线版本包含可在10.1007/s11571-022-09834-x获取的补充材料。
