Du Sha, Guan Zhuzhu, Hao Lihong, Song Yang, Wang Lan, Gong Linlin, Liu Lu, Qi Xiaoyu, Hou Zhaoyuan, Shao Shujuan
Department of Histology and Embryology, Dalian Medical University, Liaoning, China ; Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Liaoning, China.
Department of Histology and Embryology, Dalian Medical University, Liaoning, China ; Liaoning Key Laboratory of Proteomics, Dalian Medical University, Liaoning, China.
PLoS One. 2014 Jan 23;9(1):e85804. doi: 10.1371/journal.pone.0085804. eCollection 2014.
Fructose-bisphosphate aldolase A (ALDOA) is a key enzyme in glycolysis and is responsible for catalyzing the reversible conversion of fructose-1,6-bisphosphate to glyceraldehydes-3-phosphate and dihydroxyacetone phosphate. ALDOA contributes to various cellular functions such as muscle maintenance, regulation of cell shape and mobility, striated muscle contraction, actin filament organization and ATP biosynthetic process. Here, we reported that ALDOA is a highly expressed in lung squamous cell carcinoma (LSCC) and its expression level is correlated with LSCC metastasis, grades, differentiation status and poor prognosis. Depletion of ALDOA expression in the lung squamous carcinoma NCI-H520 cells reduces the capabilities of cell motility and tumorigenesis. These data suggest that ALDOA could be a potential marker for LSCC metastasis and a therapeutic target for drug development.
果糖二磷酸醛缩酶A（ALDOA）是糖酵解中的关键酶，负责催化1,6-二磷酸果糖可逆转化为3-磷酸甘油醛和磷酸二羟丙酮。ALDOA参与多种细胞功能，如肌肉维持、细胞形状和迁移调控、横纹肌收缩、肌动蛋白丝组织以及ATP生物合成过程。在此，我们报道ALDOA在肺鳞状细胞癌（LSCC）中高表达，其表达水平与LSCC转移、分级、分化状态及预后不良相关。在肺鳞状癌NCI-H520细胞中降低ALDOA表达可降低细胞迁移和肿瘤发生能力。这些数据表明，ALDOA可能是LSCC转移的潜在标志物及药物开发的治疗靶点。
