果糖二磷酸醛缩酶a是肺鳞状细胞癌潜在的转移相关标志物，可促进肺细胞肿瘤发生和迁移。

Fructose-bisphosphate aldolase a is a potential metastasis-associated marker of lung squamous cell carcinoma and promotes lung cell tumorigenesis and migration.

作者信息

Du Sha, Guan Zhuzhu, Hao Lihong, Song Yang, Wang Lan, Gong Linlin, Liu Lu, Qi Xiaoyu, Hou Zhaoyuan, Shao Shujuan

机构信息

Department of Histology and Embryology, Dalian Medical University, Liaoning, China ; Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Liaoning, China.

Department of Histology and Embryology, Dalian Medical University, Liaoning, China ; Liaoning Key Laboratory of Proteomics, Dalian Medical University, Liaoning, China.

出版信息

PLoS One. 2014 Jan 23;9(1):e85804. doi: 10.1371/journal.pone.0085804. eCollection 2014.

Fructose-bisphosphate aldolase A (ALDOA) is a key enzyme in glycolysis and is responsible for catalyzing the reversible conversion of fructose-1,6-bisphosphate to glyceraldehydes-3-phosphate and dihydroxyacetone phosphate. ALDOA contributes to various cellular functions such as muscle maintenance, regulation of cell shape and mobility, striated muscle contraction, actin filament organization and ATP biosynthetic process. Here, we reported that ALDOA is a highly expressed in lung squamous cell carcinoma (LSCC) and its expression level is correlated with LSCC metastasis, grades, differentiation status and poor prognosis. Depletion of ALDOA expression in the lung squamous carcinoma NCI-H520 cells reduces the capabilities of cell motility and tumorigenesis. These data suggest that ALDOA could be a potential marker for LSCC metastasis and a therapeutic target for drug development.