Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, Henan, China.
Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, Henan, China.
Sci Rep. 2022 Jul 8;12(1):11632. doi: 10.1038/s41598-022-15866-4.
Aldolase A (ALDOA) is an enzyme that plays an important role in glycolysis and gluconeogenesis, which is closely related to tumor metabolism. In this study, the overall roles of ALDOA in pan-cancer have been investigated from several aspects using databases and online analysis tools. Using the ONCOMINE database, the expression of ALDOA in various cancers was analyzed. The prognostic role of ALDOA was explored by PrognoScan, GEPIA, and Kaplan-Meier Plotter. The immune-related role of ALDOA and its downstream substrates was decided by TIMER, cBioPortal and String. Our data indicate that ALDOA expression level in lung adenocarcinoma, liver hepatocellular carcinoma, head and neck squamous cell carcinoma is higher than that in normal tissues. Increased expression of ALDOA often indicates a poor prognosis for patients. The correlation between ALDOA and immune infiltration among different tumors is very different. We also investigate the relationship between ALDOA and its upstream/downstream proteins. Our results showed that ALDOA could be used as a biomarker for the tumor prognosis, and could be correlated with the infiltrating levels of macrophages, CD4+ T cells and CD8+ T cells.
醛缩酶 A（ALDOA）是一种在糖酵解和糖异生中起重要作用的酶，与肿瘤代谢密切相关。本研究使用数据库和在线分析工具从多个方面探讨了 ALDOA 在多种癌症中的整体作用。通过 ONCOMINE 数据库分析了 ALDOA 在各种癌症中的表达。通过 PrognoScan、GEPIA 和 Kaplan-Meier Plotter 探讨了 ALDOA 的预后作用。通过 TIMER、cBioPortal 和 String 确定了 ALDOA 的免疫相关作用及其下游底物。我们的数据表明，肺腺癌、肝癌、头颈部鳞状细胞癌中 ALDOA 的表达水平高于正常组织。ALDOA 表达水平的增加通常预示着患者预后不良。ALDOA 与不同肿瘤中免疫浸润的相关性差异很大。我们还研究了 ALDOA 与其上游/下游蛋白之间的关系。我们的结果表明，ALDOA 可以作为肿瘤预后的生物标志物，并且与巨噬细胞、CD4+T 细胞和 CD8+T 细胞的浸润水平相关。
