Shegay Petr V, Shatova Olga P, Zabolotneva Anastasia A, Shestopalov Aleksandr V, Kaprin Andrei D
Federal State Budget Institution, National Medical Research Radiology Center of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Pirogov Russian National Research Medical University, Moscow, Russia.
Front Mol Biosci. 2023 Jun 28;10:1076138. doi: 10.3389/fmolb.2023.1076138. eCollection 2023.
Since an extensive genome research has started, basic principle "one gene-one protein-one function" was significantly revised. Many proteins with more than one function were identified and characterized as "moonlighting" proteins, which activity depend not only on structural peculiarities but also on compartmentation and metabolic environment. It turned out that "housekeeping" glycolytic enzymes show important moonlight functions such as control of development, proliferation, apoptosis, migration, regulation of transcription and cell signaling. Glycolytic enzymes emerged very early in evolution and because of the limited content of genomes, they could be used as ancient regulators for intercellular and intracellular communication. The multifunctionality of the constitutively expressed enzymes began to serve cancer cell survival and growth. In the present review we discuss some moonlight functions of glycolytic enzymes that important for malignant transformation and tumor growth.
自从广泛的基因组研究开始以来，“一个基因-一种蛋白质-一种功能”这一基本原理得到了重大修正。许多具有不止一种功能的蛋白质被鉴定出来，并被表征为“兼职”蛋白质，其活性不仅取决于结构特性，还取决于区室化和代谢环境。结果表明，“看家”糖酵解酶具有重要的兼职功能，如控制发育、增殖、凋亡、迁移、转录调控和细胞信号传导。糖酵解酶在进化过程中很早就出现了，由于基因组内容有限，它们可作为细胞间和细胞内通讯的古老调节因子。组成型表达酶的多功能性开始为癌细胞的存活和生长服务。在本综述中，我们讨论了糖酵解酶的一些对恶性转化和肿瘤生长很重要的兼职功能。
