基于全视野数字化乳腺X线摄影的乳腺体积密度估计：一项验证研究。
Volumetric breast density estimation from full-field digital mammograms: a validation study.
作者信息
Gubern-Mérida Albert, Kallenberg Michiel, Platel Bram, Mann Ritse M, Martí Robert, Karssemeijer Nico
机构信息
Department of Computer Architecture and Technology, University of Girona, Girona, Spain ; Department of Radiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Radiology, Radboud University Medical Center, Nijmegen, The Netherlands.
出版信息
PLoS One. 2014 Jan 21;9(1):e85952. doi: 10.1371/journal.pone.0085952. eCollection 2014.
OBJECTIVES
To objectively evaluate automatic volumetric breast density assessment in Full-Field Digital Mammograms (FFDM) using measurements obtained from breast Magnetic Resonance Imaging (MRI).
MATERIAL AND METHODS
A commercially available method for volumetric breast density estimation on FFDM is evaluated by comparing volume estimates obtained from 186 FFDM exams including mediolateral oblique (MLO) and cranial-caudal (CC) views to objective reference standard measurements obtained from MRI.
RESULTS
Volumetric measurements obtained from FFDM show high correlation with MRI data. Pearson's correlation coefficients of 0.93, 0.97 and 0.85 were obtained for volumetric breast density, breast volume and fibroglandular tissue volume, respectively.
CONCLUSIONS
Accurate volumetric breast density assessment is feasible in Full-Field Digital Mammograms and has potential to be used in objective breast cancer risk models and personalized screening.
目的
使用从乳腺磁共振成像（MRI）获得的测量值，客观评估全视野数字化乳腺摄影（FFDM）中的自动乳腺体积密度评估。
材料与方法
通过比较从186次FFDM检查（包括内外侧斜位（MLO）和头尾位（CC）视图）获得的体积估计值与从MRI获得的客观参考标准测量值，评估一种用于FFDM上乳腺体积密度估计的商用方法。
结果
从FFDM获得的体积测量值与MRI数据显示出高度相关性。乳腺体积密度、乳腺体积和纤维腺体组织体积的Pearson相关系数分别为0.93、0.97和0.85。
结论
在全视野数字化乳腺摄影中进行准确的乳腺体积密度评估是可行的，并且有潜力用于客观的乳腺癌风险模型和个性化筛查。
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