通过混合淋巴细胞培养产生一种能够保护巨噬细胞免受病毒感染的II型干扰素。
Production by mixed lymphocyte cultures of a type II interferon able to protect macrophages against virus infection.
作者信息
Virelizier J L, Allison A C, de Maeyer E
出版信息
Infect Immun. 1977 Aug;17(2):282-5. doi: 10.1128/iai.17.2.282-285.1977.
Abstract
In supernatants of mixed mouse spleen cell cultures established for 4 days, a species-specific inhibitor of virus replication with a broad antiviral spectrum was found. The inhibitor was destroyed by trypsin, was nondialyzable and acid labile, and was not neutralized by antibody to mouse L cell interferon. This indicates that in mixed lymphocyte cultures a type II interferon is made that has no immunological relationship with "fibroblast" interferon. This leukocyte product was shown to protect mouse hepatitis viruses. It is suggested that lymphocyte interferon may collaborate with macrophages in host defense against viruses, as a mediator of cellular immunity.
摘要
在建立4天的混合小鼠脾细胞培养上清液中，发现了一种具有广谱抗病毒活性的种属特异性病毒复制抑制剂。该抑制剂可被胰蛋白酶破坏，不可透析且对酸不稳定，并且不能被抗小鼠L细胞干扰素的抗体中和。这表明在混合淋巴细胞培养物中产生了一种与“成纤维细胞”干扰素无免疫关系的II型干扰素。这种白细胞产物被证明可保护小鼠肝炎病毒。有人提出，淋巴细胞干扰素可能作为细胞免疫的介质，在宿主抗病毒防御中与巨噬细胞协同作用。
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