Mustian Karen M, Devine Katie, Ryan Julie L, Janelsins Michelle C, Sprod Lisa K, Peppone Luke J, Candelario Grace D, Mohile Supriya G, Morrow Gary R
James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry.
US Oncol Hematol. 2011;7(2):91-97. doi: 10.17925/ohr.2011.07.2.91.
Nausea and vomiting are two of the most troubling side effects patients experience during chemotherapy. While newly available treatments have improved our ability to manage nausea and vomiting, anticipatory and delayed nausea and vomiting are still a major problem for patients receiving chemotherapy. Many cancer patients will delay or refuse future chemotherapy treatments and contemplate stopping chemotherapy altogether because of their fear of experiencing further nausea and vomiting. The purpose of this article is to provide an overview of the patho-psychophysiology of chemotherapy-induced nausea and vomiting and the recommended guidelines for treatment.
恶心和呕吐是患者在化疗期间经历的最令人困扰的两种副作用。虽然新出现的治疗方法提高了我们控制恶心和呕吐的能力,但预期性和迟发性恶心和呕吐对于接受化疗的患者来说仍然是一个主要问题。许多癌症患者会因为害怕进一步出现恶心和呕吐而推迟或拒绝未来的化疗治疗,并考虑完全停止化疗。本文的目的是概述化疗引起的恶心和呕吐的病理心理生理学以及推荐的治疗指南。