School of Nursing, Federal University of Alfenas, Gabriel Monteiro da Silva street, 700-Centro, Alfenas, MG, 30.130-100, Brazil.
School of Nursing, Federal University of Minas Gerais, Prof. Alfredo Balena avenue 190-Santa Efigênia, Belo Horizonte, MG, 37.130-001, Brazil.
Syst Rev. 2019 Aug 15;8(1):206. doi: 10.1186/s13643-019-1124-3.
Due to the worldwide rise in cancer incidence, and therefore the rise in the need for antineoplastic chemotherapy, it is important for both healthcare professionals and patients alike that the side effects of chemotherapy, such as chemotherapy-induced nausea and vomiting (CINV), are treated and prevented. Auriculotherapy is a type of acupuncture and may be a low-cost and safe antiemetic measure to control the side effects of chemotherapy. The goal of this systematic review is to synthesize the available evidence in the literature regarding the auriculotherapy effects to treat CINV in people with cancer.
The review will only include randomized controlled trials (RCTs) that compare the clinical effects of the auriculotherapy intervention (used alone or as an add-on), with sham auriculotherapy, routine treatment with antiemetic drugs, or other non-pharmacological interventions in patients with cancer with CINV who are undergoing chemotherapy. The outcomes to be evaluated are nausea and vomiting: in acute, delayed, or anticipated stages, when induced by chemotherapy. A comprehensive search for studies will be carried out in these databases: MEDLINE via PubMed, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, ICTRP, LILACS, CUMED, IBECS, BVS MTCI Americas, Web of Science, Scopus, PEDro, CNKI, and CBMdisc up until December 31, 2018. Only articles in English, Portuguese, and Spanish will be selected. Two independent reviewers will evaluate full texts, extract data, and assess the risk of bias of eligible articles. The quality of evidence will be assessed using Grading of Recommendations, Assessment, Development and Evaluation (GRADE). A meta-analysis will be undertaken to assess the interventions and outcomes' homogeneity, assessing statistical heterogeneity using the Cochran's Q test and quantified using Higgins' inconsistency index. If there is insufficient data for a meta-analysis, a narrative synthesis will be presented. This protocol has been prepared according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines.
The results of this systematic review will summarize the strength of evidence for the use of auriculotherapy in the control of CINV of patients with cancer and will be used to identify evidence gaps.
PROSPERO CRD42018117513.
由于癌症发病率在全球范围内的上升，因此抗肿瘤化疗的需求也随之上升，对于医疗保健专业人员和患者来说，化疗引起的恶心和呕吐（CINV）等化疗副作用的治疗和预防都很重要。耳针疗法是一种针灸疗法，可能是一种低成本且安全的止吐措施，可控制化疗的副作用。本系统评价的目的是综合文献中关于耳针疗法治疗癌症患者 CINV 的可用证据。
本综述仅纳入比较耳针疗法干预（单独使用或作为附加治疗）与假耳针、常规止吐药物治疗或癌症患者 CINV 化疗时其他非药物干预的临床效果的随机对照试验（RCT）。将要评估的结局是恶心和呕吐：在急性、延迟或预期阶段，由化疗引起。将在以下数据库中全面搜索研究：通过 PubMed 检索 MEDLINE、EMBASE、CINAHL、Cochrane 中央对照试验注册库、ICTRP、LILACS、CUMED、IBECS、BVS MTCI 美洲、Web of Science、Scopus、PEDro、CNKI 和 CBMdisc，检索时间截至 2018 年 12 月 31 日。仅选择英文、葡萄牙文和西班牙文的文章。两名独立的审查员将评估全文、提取数据并评估合格文章的偏倚风险。使用推荐评估、制定与评价（GRADE）对证据质量进行评估。如果存在足够的数据进行 meta 分析，将评估干预措施和结局的同质性，使用 Cochran's Q 检验评估统计学异质性，并使用 Higgins 不一致性指数进行量化。如果没有足够的数据进行 meta 分析，将呈现叙述性综合。本方案是根据系统评价和荟萃分析报告的首选报告项目（PRISMA-P）指南制定的。
本系统评价的结果将总结耳针疗法控制癌症患者 CINV 的证据强度，并用于确定证据差距。
PROSPERO CRD42018117513。
