维生素D被发现之前的佝偻病
Rickets before the discovery of vitamin D.
作者信息
O'Riordan Jeffrey L H, Bijvoet Olav L M
机构信息
University College London , London, UK.
University of Leiden , Haarlem, The Netherlands.
出版信息
Bonekey Rep. 2014 Jan 8;3:478. doi: 10.1038/bonekey.2013.212.
The story of rickets leading to the discovery of vitamin D is an extraordinary tale, spread over many centuries and involving some remarkable characters with much speculation and a few mysteries, before reaching an exciting climax. It would be wrong to credit a single person as discovering rickets or being the first to describe its features, for reasons that will be set out here. Yet the emergence of the term 'rickets' is as important as the discovery of vitamin D itself and the possible causes of its deficiency. It permitted identification of a hitherto ill-defined disease entity, typically occurring in infants and children. It also provided a way for deciding if features of diseases that had been described earlier in the history of medicine could be seen as the symptoms and signs of related conditions.
佝偻病促使维生素D被发现的故事是非同寻常的，它跨越了多个世纪，涉及一些杰出人物，充满了诸多猜测和一些谜团，最终迎来了激动人心的高潮。将佝偻病的发现归功于某一个人，或者认为某一个人是第一个描述其特征的，这种做法是错误的，原因将在此阐述。然而，“佝偻病”这一术语的出现与维生素D本身的发现以及其缺乏的可能原因同样重要。它使人们能够识别一种此前定义不明确的疾病实体，这种疾病通常发生在婴幼儿身上。它还提供了一种方法，来判定医学史上早期所描述疾病的特征是否可被视为相关病症的症状和体征。
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