Anton Stephen D, Karabetian Christy, Heekin Kacey, Leeuwenburgh Christiaan
Department of Aging and Geriatric Research, Institute on Aging, 2004 E. Mowry Road, University of Florida, Gainesville, FL 32610, (352) 273-7514.
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32610, (352) 273-7514.
Curr Transl Geriatr Exp Gerontol Rep. 2013 Dec 13;2(4):239-246. doi: 10.1007/s13670-013-0062-5.
As life expectancy in the United States continues to increase, the maintenance of physical independence among older Americans has emerged as a major clinical and public health priority. Therefore, there is an urgent need to identify interventions that can maintain or enhance cognitive and physical function with the goal of preventing or delaying the onset of disability. To date, caloric restriction (CR) is the only method that has been consistently found to increase lifespan and delay the onset of age-associated diseases such as cancer and diabetes across multiple species. The promise of calorie restriction as an intervention to improve health and/or maintain function in humans, however, only holds if individuals are able to adhere to this intervention over the long-term. Unfortunately, long-term adherence to CR regimens is notoriously poor likely due to complex interactions between behavioral, physiological, psychological, and environmental variables. Thus, a current challenge for both researchers and clinicians is to identify methods that can assist individuals in maintaining CR over the long-term.
随着美国人均寿命持续增长，保持美国老年人身体独立已成为临床和公共卫生领域的一项重大优先事项。因此，迫切需要确定能够维持或增强认知和身体功能的干预措施，以预防或延缓残疾的发生。迄今为止，热量限制（CR）是唯一一种在多个物种中均被一致发现可延长寿命并延缓癌症和糖尿病等与年龄相关疾病发病的方法。然而，热量限制作为一种改善人类健康和/或维持功能的干预措施，只有在个体能够长期坚持这种干预的情况下才具有前景。不幸的是，长期坚持CR方案的情况 notoriously 较差，这可能是由于行为、生理、心理和环境变量之间的复杂相互作用所致。因此，研究人员和临床医生目前面临的一个挑战是确定能够帮助个体长期维持CR的方法。
