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经颈静脉肝内门体分流术与球囊闭塞逆行静脉栓塞术治疗孤立性胃静脉曲张的短期再出血率比较

Short-term rebleeding rates for isolated gastric varices managed by transjugular intrahepatic portosystemic shunt versus balloon-occluded retrograde transvenous obliteration.

作者信息

Sabri Saher S, Abi-Jaoudeh Nadine, Swee Warren, Saad Wael E, Turba Ulku C, Caldwell Stephen H, Angle John F, Matsumoto Alan H

机构信息

Division of Angiography, Interventional Radiology, and Special Procedures, University of Virginia Health System, 1215 Lee Street/Box 800170, Charlottesville, VA 22908.

Department of Diagnostic Radiology, National Institutes of Health, Bethesda, Maryland.

出版信息

J Vasc Interv Radiol. 2014 Mar;25(3):355-61. doi: 10.1016/j.jvir.2013.12.001. Epub 2014 Jan 24.

Abstract

PURPOSE

To assess the short-term rebleeding rate associated with the use of a transjugular intrahepatic portosystemic shunt (TIPS) compared with balloon-occluded retrograde transvenous obliteration (BRTO) for management of gastric varices (GV).

MATERIALS AND METHODS

A single-center retrospective comparison of 50 patients with bleeding from GV treated with a TIPS or BRTO was performed. Of 50 patients, 27 (17 men and 10 women; median age, 55 y; range, 31-79 y) received a TIPS with covered stents, and 23 (12 men and 11 women; median age, 52 y; range, 23-83 y) underwent a BRTO procedure with a foam sclerosant. All study subjects had clinical and endoscopic evidence of isolated bleeding GV and were hemodynamically stable at the time of the procedure. Clinical and endoscopic follow-up was performed. Kaplan-Meier analysis was used to evaluate rebleeding rates from the GV.

RESULTS

The technical success rate was 100% in the TIPS group and 91% in the BRTO group (P = .21). Major complications occurred in 4% of the patients receiving TIPS and 9% of patients the undergoing BRTO (P = .344). Encephalopathy was reported in 4 of 27 (15%) patients in the TIPS group and in none of the patients in the BRTO group (0%; P = .12). At 12 months, the incidence of rebleeding from a GV source was 11% in the TIPS group and 0% in the BRTO group (P = .25).

CONCLUSIONS

BRTO appears to be equivalent to TIPS in the short-term for management of bleeding GV. Further comparative studies are warranted to determine optimal management strategies in individual patients.

摘要

目的

评估与使用经颈静脉肝内门体分流术(TIPS)相比,球囊闭塞逆行静脉栓塞术(BRTO)治疗胃静脉曲张(GV)的短期再出血率。

材料与方法

对50例接受TIPS或BRTO治疗的GV出血患者进行单中心回顾性比较。50例患者中,27例(17例男性和10例女性;中位年龄55岁;范围31 - 79岁)接受带覆膜支架的TIPS治疗,23例(12例男性和11例女性;中位年龄52岁;范围23 - 83岁)接受泡沫硬化剂BRTO手术。所有研究对象均有孤立性GV出血的临床和内镜证据,且在手术时血流动力学稳定。进行了临床和内镜随访。采用Kaplan - Meier分析评估GV的再出血率。

结果

TIPS组技术成功率为100%,BRTO组为91%(P = 0.21)。接受TIPS治疗的患者中有4%发生主要并发症,接受BRTO治疗的患者中有9%发生主要并发症(P = 0.344)。TIPS组27例患者中有4例(15%)报告发生肝性脑病,BRTO组患者无一例发生(0%;P = 0.12)。12个月时,TIPS组GV源再出血发生率为11%,BRTO组为0%(P = 0.25)。

结论

在短期治疗GV出血方面,BRTO似乎与TIPS等效。有必要进行进一步的比较研究以确定个体患者的最佳治疗策略。

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