Sabri Saher S, Abi-Jaoudeh Nadine, Swee Warren, Saad Wael E, Turba Ulku C, Caldwell Stephen H, Angle John F, Matsumoto Alan H
Division of Angiography, Interventional Radiology, and Special Procedures, University of Virginia Health System, 1215 Lee Street/Box 800170, Charlottesville, VA 22908.
Department of Diagnostic Radiology, National Institutes of Health, Bethesda, Maryland.
J Vasc Interv Radiol. 2014 Mar;25(3):355-61. doi: 10.1016/j.jvir.2013.12.001. Epub 2014 Jan 24.
To assess the short-term rebleeding rate associated with the use of a transjugular intrahepatic portosystemic shunt (TIPS) compared with balloon-occluded retrograde transvenous obliteration (BRTO) for management of gastric varices (GV).
A single-center retrospective comparison of 50 patients with bleeding from GV treated with a TIPS or BRTO was performed. Of 50 patients, 27 (17 men and 10 women; median age, 55 y; range, 31-79 y) received a TIPS with covered stents, and 23 (12 men and 11 women; median age, 52 y; range, 23-83 y) underwent a BRTO procedure with a foam sclerosant. All study subjects had clinical and endoscopic evidence of isolated bleeding GV and were hemodynamically stable at the time of the procedure. Clinical and endoscopic follow-up was performed. Kaplan-Meier analysis was used to evaluate rebleeding rates from the GV.
The technical success rate was 100% in the TIPS group and 91% in the BRTO group (P = .21). Major complications occurred in 4% of the patients receiving TIPS and 9% of patients the undergoing BRTO (P = .344). Encephalopathy was reported in 4 of 27 (15%) patients in the TIPS group and in none of the patients in the BRTO group (0%; P = .12). At 12 months, the incidence of rebleeding from a GV source was 11% in the TIPS group and 0% in the BRTO group (P = .25).
BRTO appears to be equivalent to TIPS in the short-term for management of bleeding GV. Further comparative studies are warranted to determine optimal management strategies in individual patients.
评估与使用经颈静脉肝内门体分流术(TIPS)相比,球囊闭塞逆行静脉栓塞术(BRTO)治疗胃静脉曲张(GV)的短期再出血率。
对50例接受TIPS或BRTO治疗的GV出血患者进行单中心回顾性比较。50例患者中,27例(17例男性和10例女性;中位年龄55岁;范围31 - 79岁)接受带覆膜支架的TIPS治疗,23例(12例男性和11例女性;中位年龄52岁;范围23 - 83岁)接受泡沫硬化剂BRTO手术。所有研究对象均有孤立性GV出血的临床和内镜证据,且在手术时血流动力学稳定。进行了临床和内镜随访。采用Kaplan - Meier分析评估GV的再出血率。
TIPS组技术成功率为100%,BRTO组为91%(P = 0.21)。接受TIPS治疗的患者中有4%发生主要并发症,接受BRTO治疗的患者中有9%发生主要并发症(P = 0.344)。TIPS组27例患者中有4例(15%)报告发生肝性脑病,BRTO组患者无一例发生(0%;P = 0.12)。12个月时,TIPS组GV源再出血发生率为11%,BRTO组为0%(P = 0.25)。
在短期治疗GV出血方面,BRTO似乎与TIPS等效。有必要进行进一步的比较研究以确定个体患者的最佳治疗策略。