Zuo Hui, Shi Zumin, Hussain Akhtar
Department of Nutrition and Food Hygiene, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China; Section for International Health, Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.
Department of Nutrition and Food Hygiene, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China; Discipline of Medicine, University of Adelaide, Adelaide, Australia.
Diabetes Res Clin Pract. 2014 Apr;104(1):63-72. doi: 10.1016/j.diabres.2014.01.002. Epub 2014 Jan 8.
To describe the prevalence and trends of diabetes and to quantitatively assess its risk factors in mainland China.
Thirty-one epidemiological studies were identified by a systematic search of four databases. Prevalence estimates were mapped and summarized by meta-analysis in each region of China. The pooled ORs and 95% CIs of risk factors for diabetes were also calculated.
There was a large geographical imbalance with regard to the prevalence of diabetes. Region-pooled prevalence was highest in the eastern region (8.0%, 95% CI: 6.1-10.0%) and lowest in the western region (4.6%, 95% CI: 3.3-6.0%), which was consistent with regional levels of economic development. The overall prevalence of diabetes has been increasing since 1980. Traditional risk factors such as age, family history of diabetes, obesity, hypertension and elevated triglycerides were found to be associated with diabetes. In addition, urban residence and being from ethnic minorities were also significantly associated.
Based on the meta-analyses, we found that the prevalence of diabetes is different in different parts of China but it has been increasing sharply during the last three decades. Some risk factors were quantitatively derived in the study, which are free from the diversity of a single sample.
描述中国大陆糖尿病的患病率及趋势，并对其危险因素进行定量评估。
通过系统检索四个数据库确定了31项流行病学研究。在中国各地区通过荟萃分析对患病率估计值进行绘制和总结。还计算了糖尿病危险因素的合并比值比（OR）和95%置信区间（CI）。
糖尿病患病率存在很大的地区差异。按地区汇总的患病率在东部地区最高（8.0%，95%CI：6.1 - 10.0%），在西部地区最低（4.6%，95%CI：3.3 - 6.0%），这与地区经济发展水平一致。自1980年以来，糖尿病的总体患病率一直在上升。发现年龄、糖尿病家族史、肥胖、高血压和甘油三酯升高这些传统危险因素与糖尿病有关。此外，城市居住和少数民族身份也与糖尿病显著相关。
基于荟萃分析，我们发现中国不同地区糖尿病患病率不同，但在过去三十年中急剧上升。本研究定量得出了一些危险因素，避免了单个样本的局限性。
