Arboviruses and Haemorrhagic Fever Viruses Unit, Virology Department, Institut Pasteur de Dakar, Dakar BP 220, Senegal.
Department of Animal Biology, Faculty of Science et Technics, Université Cheikh Anta Diop de Dakar(UCAD), Fann BP 5005, Dakar, Senegal.
Viruses. 2021 Jan 4;13(1):57. doi: 10.3390/v13010057.
Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades. Dengue is caused by genetically distinct serotypes, DENV-1-4. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and Mali (Western Africa) in 2015-2019, that were analyzed by sequencing the envelope (E) gene. The emergence and the dynamics of DENV-1 in Western Africa were inferred by using maximum likelihood and Bayesian methods. The DENV-1 grouped into a monophyletic cluster that was closely related to those from Southeast Asia. The virus appears to have been introduced directly into Medina Gounass (Suburb of Dakar), Senegal (location probability = 0.301, posterior = 0.76). The introduction of the virus in Senegal occurred around 2014 (95% HPD = 2012.88-2014.84), and subsequently, the virus moved to regions within Senegal (e.g., Louga and Fatick), causing intense outbreaks in the subsequent years. The virus appears to have been introduced in Mali (a neighboring country) after its introduction in Senegal. In conclusion, we present evidence that the outbreak caused by DENV-1 in urban environments in Senegal and Mali after 2015 was caused by a single viral introduction from Asia.
登革热病毒（DENV）是分布最广泛的虫媒病毒，近几十年来，世界范围内的登革热疫情数量和严重程度都在增加。登革热由遗传上不同的血清型引起，即 DENV-1-4。在这里，我们展示了 2015-2019 年期间在塞内加尔和马里（西非）爆发的登革热患者中分离到的 DENV-1 的数据，这些数据通过对包膜（E）基因进行测序进行了分析。使用最大似然法和贝叶斯方法推断了 DENV-1 在西非的出现和动态。DENV-1 聚成一个单系群，与来自东南亚的病毒密切相关。该病毒似乎是直接传入塞内加尔的 Medina Gounass（达喀尔郊区）（位置概率=0.301，后验概率=0.76）。该病毒在塞内加尔的传入时间约为 2014 年（95% HPD=2012.88-2014.84），随后该病毒传播到塞内加尔的其他地区（如 Louga 和 Fatick），导致随后几年爆发了严重疫情。该病毒似乎是在塞内加尔传入后传入马里（邻国）的。总之，我们的研究结果表明，2015 年后塞内加尔和马里城市环境中发生的 DENV-1 暴发是由亚洲单一病毒传入引起的。
