Karas Johannis Andreas, Bradshaw Simon, Mahmud Wabbas, Enoch David A
Clinical Microbiology & Public Health Laboratory, Health Protection Agency, Papworth Hospital, Cambridge, UK; ; Hinchingbrooke Hospital, Hinchingbrooke Health Care NHS Trust, Huntingdon, UK.
Hinchingbrooke Hospital, Hinchingbrooke Health Care NHS Trust, Huntingdon, UK.
Infect Dis Rep. 2010 Jun 21;2(1):e8. doi: 10.4081/idr.2010.e8. eCollection 2010 Feb 3.
Clostridium difficile is the most common cause of hospital acquired infectious diarrhea in the developed world and has re-emerged in recent years with apparent greater morbidity and mortality. Despite this, there is little recent published data from the UK concerning associated mortality. We performed a case control study at a UK district general hospital of 66 hospitalized patients over the age of 65 years with C. difficile infection compared to 3-5 controls matched for age, sex and minimum length of stay. We found a significant excess mortality of 11.5% at seven days, 26.2% at 30 days, 38.1% at 90 days and 41.4% at 180 days. C. difficile infection in hospitalized elderly patients may contribute to long-term mortality or be a marker of poor prognosis and cases may require more intensive long-term follow up to improve mortality.
艰难梭菌是发达国家医院获得性感染性腹泻最常见的病因，近年来再度出现，其发病率和死亡率明显更高。尽管如此，英国近期几乎没有关于相关死亡率的公开数据。我们在英国一家地区综合医院进行了一项病例对照研究，研究对象为66名65岁以上住院的艰难梭菌感染患者，并与3至5名年龄、性别和最短住院时间相匹配的对照者进行比较。我们发现，7天时的死亡率显著高出11.5%，30天时高出26.2%，90天时高出38.1%，180天时高出41.4%。住院老年患者的艰难梭菌感染可能导致长期死亡，或者是预后不良的一个指标，对于这些病例可能需要更密集的长期随访以降低死亡率。
