Nkoghe Dieudonné, Kassa Roland Fabrice Kassa, Bisvigou Ulrich, Caron Mélanie, Grard Gilda, Leroy Eric Maurice
Unité des Maladies Virales Emergentes, Centre International de Recherches Médicales de Franceville (CIRMF), Franceville; ; Ministère de la Santé Publique, Libreville;
Unité des Maladies Virales Emergentes, Centre International de Recherches Médicales de Franceville (CIRMF), Franceville;
Infect Dis Rep. 2012 Jan 3;4(1):e5. doi: 10.4081/idr.2012.e5. eCollection 2012 Jan 2.
Chikungunya (CHIKV) and Dengue (DENV) viruses, both arboviruses, have caused multiple outbreaks worldwide. Their clinical features are poorly described in Africa and there is no comparative study, although Chikungunya is considered as a dengue-like disease. We conducted a comparative study of clinical and biological data from CHIKV and DENV positive patients during the 2010 Gabonese outbreak. Patients consulting with general symptoms and having laboratory confirmation for CHIKV or DENV were included. Clinical and biological data were recorded. Statistical analyses were performed using Epi Info. A P value < 0.05 was considered significant. In all, 270 CHIKV+, 53 DENV+ and 20 co-infected patients were included in the study. Headaches, hemorrhage, leukopenia and lymphopenia were significantly (P respectively 0.01, 0.001, 0.02 and 0.001) more frequent in DENV+ patients than in CHIKV+. There was no additive effect of the two viruses.These clinical and hematological disorders are non specific and cannot assist for the differential diagnosis. These diseases are clinically indistinguishable, and need for laboratory confirmation.
基孔肯雅病毒（CHIKV）和登革热病毒（DENV）均为虫媒病毒，已在全球多地引发多次疫情。尽管基孔肯雅热被视为一种类似登革热的疾病，但在非洲，对它们临床特征的描述较少，且尚无比较研究。我们对2010年加蓬疫情期间CHIKV和DENV阳性患者的临床及生物学数据进行了一项比较研究。纳入有一般症状且实验室确诊为CHIKV或DENV的患者。记录临床及生物学数据。使用Epi Info进行统计分析。P值<0.05被视为具有统计学意义。该研究共纳入270例CHIKV阳性、53例DENV阳性及20例合并感染患者。DENV阳性患者出现头痛、出血、白细胞减少和淋巴细胞减少的情况显著（P值分别为0.01、0.001、0.02和0.001）多于CHIKV阳性患者。两种病毒不存在叠加效应。这些临床和血液学紊乱并无特异性，无法用于鉴别诊断。这两种疾病在临床上难以区分，需要实验室确诊。
