Cecchini Diego M, Cañizal Ana M, Rojas Haroldo, Arechavala Alicia, Negroni Ricardo, Bouzas María B, Benetucci Jorge A
Infectious Diseases Department.
Virology Unit and.
Infect Dis Rep. 2012 Apr 24;4(2):e30. doi: 10.4081/idr.2012.e30. eCollection 2012 Apr 27.
In order to determine HIV-1 kinetics in cerebrospinal fluid (CSF) and plasma in patients with cryptococcal meningitis (CM), we undertook a prospective collection of paired CSF/plasma samples from antiretroviral therapy-free HIV-infected patients with CM. Samples were obtained at baseline (S1) and at the second (S2) and third (S3) weeks of antifungal therapy. HIV-1 CSF concentrations were significantly lower in both S2 and S3 with respect to S1. Plasma concentrations remained stable. HIV-1 concentrations were higher in plasma than CSF in all cases. Patients who survived the episode of CM (but not those who died) showed a decrease in CSF viral load, what suggests different viral kinetics of HIV-1 in the CSF according to the clinical course of this opportunistic disease.
为了确定隐球菌性脑膜炎（CM）患者脑脊液（CSF）和血浆中的HIV-1动力学，我们前瞻性收集了未接受抗逆转录病毒治疗的CM HIV感染患者的配对CSF/血浆样本。样本在基线（S1）以及抗真菌治疗的第二周（S2）和第三周（S3）采集。与S1相比，S2和S3时HIV-1脑脊液浓度均显著降低。血浆浓度保持稳定。在所有病例中，血浆中的HIV-1浓度均高于脑脊液。在CM发作中存活的患者（而非死亡患者）脑脊液病毒载量下降，这表明根据这种机会性疾病的临床病程，HIV-1在脑脊液中的病毒动力学有所不同。
