Wittayalai Sawangjitt, Mahidol Chulabhorn, Prachyawarakorn Vilailak, Prawat Hunsa, Ruchirawat Somsak
Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, Thailand.
Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, Thailand; Chulabhorn Graduate Institute and Center for Environmental Health and Toxicology (EHT), Kamphaeng Phet 6 Road, Bangkok 10210, Thailand.
Phytochemistry. 2014 Mar;99:121-6. doi: 10.1016/j.phytochem.2013.12.017. Epub 2014 Jan 25.
Seven terpenoids consisting of five sesquiterpenoids, hoaensieremone, hoaensieremodione, hoaensifuranonal, hoaensieudesone, and hoaensibenzofuranal, and two friedelane triterpenoids, 3α-(E)-p-coumaroyloxyfriedelan-7-one and 3α-(E)-caffeoyloxyfriedelan-7-one were isolated from the dichloromethane extract of the roots of Drypetes hoaensis. Additionally, twelve known compounds and vanillin were isolated. Their structures were established on the basis of spectroscopic analysis, as well as by comparison with literature data. The anticancer activity of nine of these compounds was investigated.
从霍氏核果木根的二氯甲烷提取物中分离出七种萜类化合物，其中包括五种倍半萜类化合物，即霍氏核果木酮、霍氏核果木二酮、霍氏核果木呋喃酮、霍氏核果木去氧酮和霍氏核果木苯并呋喃醛，以及两种木栓烷三萜类化合物，即3α-(E)-对香豆酰氧基木栓烷-7-酮和3α-(E)-咖啡酰氧基木栓烷-7-酮。此外，还分离出了十二种已知化合物和香草醛。它们的结构通过光谱分析以及与文献数据比较得以确定。对其中九种化合物的抗癌活性进行了研究。
