Chiou Chun-Tang, Shen Chien-Chang, Tsai Tung-Hu, Chen Yu-Jen, Lin Lie-Chwen
National Research Institute of Chinese Medicine , Ministry of Health and Welfare, Taipei, Taiwan.
Institute of Traditional Medicine, National Yang-Ming University , Taipei, Taiwan.
J Nat Prod. 2016 Oct 28;79(10):2439-2445. doi: 10.1021/acs.jnatprod.6b00170. Epub 2016 Oct 7.
Six new meroterpenoids, diplomeroterpenoids A-F (1-6), two new chalcone-lignoids, diplochalcolins A and B (7, 8), and 13 known compounds were isolated from the root extract of Mimosa diplotricha. Diplomeroterpenoids A-F consist of a 4H-chromen-4-one and a diterpenoid unit, and their absolute configurations were determined by X-ray crystallographic analysis. Compounds 1-3 and 5 showed potent inhibitory activity on protein farnesyl transferase, with IC values from 5.0 to 8.5 μM. Compound 1 showed antiproliferative activity against human hepatoblastoma HepG2 cells with a GI value of approximately 8.6 μM.
从含羞草的根提取物中分离出6个新的半萜类化合物，双聚萜类化合物A - F（1 - 6），2个新的查耳酮 - 木脂素类化合物，双聚查耳酮A和B（7, 8），以及13个已知化合物。双聚萜类化合物A - F由一个4H - 色烯 - 4 - 酮和一个二萜单元组成，其绝对构型通过X射线晶体学分析确定。化合物1 - 3和5对蛋白质法尼基转移酶显示出强效抑制活性，IC值为5.0至8.5μM。化合物1对人肝癌HepG2细胞显示出抗增殖活性，GI值约为8.6μM。
