两面针中吲哚生物碱的细胞毒性甘露吡喃糖苷。
Cytotoxic mannopyranosides of indole alkaloids from Zanthoxylum nitidum.
作者信息
Hu Jiang, Shi Xiaodong, Mao Xia, Chen Jiangang, Li Hui
机构信息
College of Biological Resources and Environment Science, Qujing Normal University, Sanjiang Avenue, Unicorn District, Qujing 655011, P. R. China, (phone/fax: +86-874-8998627); Institute of Characteristic Medicinal Resource of Ethnic Minorities, Qujing Normal University, Qujing 655011, P. R. China.
出版信息
Chem Biodivers. 2014 Jun;11(6):970-4. doi: 10.1002/cbdv.201300381.
Three new mannopyranosides of indole alkaloids, methyl 7-(β-D-mannopyranosyloxy)-1H-indole-2-carboxylate (1), methyl 7-[(3-O-acetyl-β-D-mannopyranosyl)oxy]-1H-indole-2-carboxylate (2), and 2-methyl-1H-indol-7-yl β-D-mannopyranoside (3), were isolated from an EtOH extract of the roots of Zanthoxylum nitidum. Their structures were identified as new compounds on the basis of the spectroscopic analyses. Bioactivity evaluation revealed that these alkaloids possess significant cytotoxicities against all the tested tumor cell lines with IC50 values of less than 30 μM.
从两面针根的乙醇提取物中分离出三种新的吲哚生物碱甘露吡喃糖苷，7-(β-D-甘露吡喃糖氧基)-1H-吲哚-2-羧酸甲酯(1)、7-[(3-O-乙酰基-β-D-甘露吡喃糖基)氧基]-1H-吲哚-2-羧酸甲酯(2)和2-甲基-1H-吲哚-7-基β-D-甘露吡喃糖苷(3)。基于光谱分析，它们的结构被鉴定为新化合物。生物活性评价表明，这些生物碱对所有测试的肿瘤细胞系都具有显著的细胞毒性，IC50值小于30 μM。
Zotero 插件