Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, People's Republic of China.
Invest Ophthalmol Vis Sci. 2014 Feb 24;55(2):1088-94. doi: 10.1167/iovs.13-13591.
To measure levels of various inflammation-related cytokines in the aqueous humor of patients with acute primary angle-closure (APAC) and senile cataract.
Aqueous humor samples were prospectively collected from 23 eyes (12 eyes with current APAC and 11 eyes with previous APAC) of 23 APAC patients and 15 eyes of 15 cataract patients. The levels of 15 inflammation-related cytokines in the aqueous humor of APAC and cataract subjects were measured by using the multiplex bead immunoassay technique. Data on patient demographics and preoperative intraocular pressure (IOP) were also collected for correlation analysis.
Compared with the group with previous APAC and the cataract group, the group with current APAC showed clear and significantly elevated concentrations of interleukin (IL)-6, IL-8, granulocyte colony-stimulating factor (G-CSF), monocyte chemotactic protein (MCP)-1, MCP-3, and vascular endothelial growth factor (VEGF) (all P < 0.0167). The group with previous APAC and the cataract group had similar levels of cytokines. Intraocular pressure was positively correlated with IL-8 (P = 0.001), G-CSF (P = 0.002), MCP-3 (P < 0.001), and VEGF (P < 0.001).
An early "acute inflammatory" condition occurs in eyes with current APAC. In addition to controlling IOP, anti-inflammatory treatments are necessary for eyes suffering from APAC.
测量急性原发性闭角型青光眼（APAC）和老年性白内障患者房水中各种炎症相关细胞因子的水平。
前瞻性收集 23 例（12 例当前 APAC 和 11 例既往 APAC）APAC 患者和 15 例白内障患者的 23 只眼房水样本。采用多因子珠免疫分析技术检测房水中 15 种炎症相关细胞因子的水平。收集患者人口统计学和术前眼压（IOP）数据进行相关分析。
与既往 APAC 组和白内障组相比，当前 APAC 组白细胞介素（IL）-6、IL-8、粒细胞集落刺激因子（G-CSF）、单核细胞趋化蛋白（MCP）-1、MCP-3 和血管内皮生长因子（VEGF）的浓度明显升高（均 P<0.0167）。既往 APAC 组和白内障组细胞因子水平相似。眼内压与 IL-8（P=0.001）、G-CSF（P=0.002）、MCP-3（P<0.001）和 VEGF（P<0.001）呈正相关。
当前 APAC 眼出现早期“急性炎症”状态。除了控制眼压外，APAC 患者还需要进行抗炎治疗。
