Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
National Clinical Research Center for Eye Diseases, Shanghai, China.
Front Immunol. 2022 Mar 22;13:847937. doi: 10.3389/fimmu.2022.847937. eCollection 2022.
Retinal degenerative diseases are a leading cause of vision loss and blindness throughout the world, characterized by chronic and progressive loss of neurons and/or myelin. One of the common features of retinal degenerative diseases and central neurodegenerative diseases is chronic neuroinflammation. Interleukin-17A (IL-17A) is the cytokine most closely related to disease in its family. Accumulating evidence suggests that IL-17A plays a key role in human retinal degenerative diseases, including age-related macular degeneration, diabetic retinopathy and glaucoma. This review aims to provide an overview of the role of IL-17A participating in the pathogenesis of retinal degenerative diseases, which may open new avenues for potential therapeutic interventions.
视网膜退行性疾病是全球范围内导致视力丧失和失明的主要原因，其特征为神经元和/或髓鞘的慢性进行性丧失。视网膜退行性疾病和中枢神经退行性疾病的一个共同特征是慢性神经炎症。白细胞介素-17A（IL-17A）是与其家族疾病最密切相关的细胞因子。越来越多的证据表明，IL-17A 在包括年龄相关性黄斑变性、糖尿病视网膜病变和青光眼在内的人类视网膜退行性疾病的发病机制中起关键作用。本综述旨在概述 IL-17A 参与视网膜退行性疾病发病机制的作用，这可能为潜在的治疗干预开辟新途径。
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