Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR (China).
Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1877-80. doi: 10.1002/anie.201309855. Epub 2014 Jan 29.
An iridium-catalyzed azide-alkyne cycloaddition reaction (IrAAC) of electron-rich internal alkynes is described. It is the first efficient intermolecular AAC of internal thioalkynes. The reaction exhibits remarkable features, such as high efficiency and regioselectivity, mild reaction conditions, easy operation, and excellent compatibility with air and a broad spectrum of organic and aqueous solvents. It complements the well-known CuAAC and RuAAC click reactions.
描述了铱催化的富电子内炔烃叠氮-炔烃环加成反应（IrAAC）。这是首例高效的内硫代炔烃的分子间 AAC。该反应具有高效、区域选择性、反应条件温和、操作简便以及对空气、各种有机溶剂和水溶剂有良好的兼容性等显著特点。它补充了著名的 CuAAC 和 RuAAC 点击反应。
