光活化钌(II)配合物催化的生物正交叠氮-硫代炔烃环加成反应。
Bioorthogonal Azide-Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes.
机构信息
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Misión Biológica de Galicia, Consejo Superior de Investigaciones Científicas (CSIC), 36080, Pontevedra, Spain.
出版信息
Angew Chem Int Ed Engl. 2021 Jul 12;60(29):16059-16066. doi: 10.1002/anie.202103645. Epub 2021 Jun 16.
Tailored ruthenium sandwich complexes bearing photoresponsive arene ligands can efficiently promote azide-thioalkyne cycloaddition (RuAtAC) when irradiated with UV light. The reactions can be performed in a bioorthogonal manner in aqueous mixtures containing biological components. The strategy can also be applied for the selective modification of biopolymers, such as DNA or peptides. Importantly, this ruthenium-based technology and the standard copper-catalyzed azide-alkyne cycloaddition (CuAAC) proved to be compatible and mutually orthogonal.
具有光响应性芳基配体的定制钌夹心配合物在紫外光照射下可以有效地促进叠氮-硫代炔烃环加成（RuAtAC）。反应可以在含有生物成分的水混合物中以生物正交的方式进行。该策略还可用于生物聚合物（如 DNA 或肽）的选择性修饰。重要的是，该基于钌的技术和标准的铜催化叠氮-炔环加成（CuAAC）被证明是兼容和相互正交的。
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