He Ya-zhou, Hu Xin, Chi Xiao-sa, Zhang Yuan-chuan, Deng Xiang-Bing, Wei Ming-tian, Wang Zi-qiang, Zhou Yan-hong
West China School of Medicine/West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, People's Republic of China.
Tumour Biol. 2014 Jan;35(1):615-21. doi: 10.1007/s13277-013-1085-4. Epub 2013 Aug 17.
Study results on the association between RAD51 gene -135G/C polymorphism and risk of myelodysplastic syndrome (MDS) or acute leukemia are inconsistent. A meta-analysis was conducted to identify the association. A systematic search was performed in PubMed, Embase, CNKI, VIP, Wanfang databases to collect all relevant studies until January 2013. Meta-analysis was carried out using fixed/random model by Review Manager 5.1 and STATA10.0. A total of 10 eligible studies with 2,656 patients and 3,725 controls were included in meta-analysis. Significant association was detected between -135G/C polymorphism and increased MDS risk (CC + GC vs. GG: OR = 1.46, 95% CI = 1.11-1.92; CC vs. GC + GG: OR = 2.45, 95% CI = 1.23-4.89), while no association was observed for acute leukemia. Subgroup analysis by subtypes of acute leukemia and ethnicity showed no significant results either. Our meta-analysis indicated that the -135G/C polymorphism might be associated with increased susceptibility of MDS. However, lack of evidence supported association of this polymorphism with acute leukemia. Additional well-designed studies with larger samples are required to verify our results.
关于RAD51基因-135G/C多态性与骨髓增生异常综合征（MDS）或急性白血病风险之间关联的研究结果并不一致。进行了一项荟萃分析以确定这种关联。在PubMed、Embase、中国知网、维普、万方数据库中进行了系统检索，以收集截至2013年1月的所有相关研究。使用Review Manager 5.1和STATA10.0软件，采用固定/随机模型进行荟萃分析。共有10项符合条件的研究，包括2656例患者和3725例对照被纳入荟萃分析。检测到-135G/C多态性与MDS风险增加之间存在显著关联（CC + GC vs. GG：OR = 1.46，95% CI = 1.11 - 1.92；CC vs. GC + GG：OR = 2.45，95% CI = 1.23 - 4.89），而未观察到与急性白血病存在关联。按急性白血病亚型和种族进行的亚组分析也未显示出显著结果。我们的荟萃分析表明，-135G/C多态性可能与MDS易感性增加有关。然而，缺乏证据支持这种多态性与急性白血病的关联。需要更多设计良好且样本量更大的研究来验证我们的结果。
