糖尿病肾病与抗氧化剂
Diabetic nephropathy and antioxidants.
作者信息
Tavafi Majid
机构信息
Department of Anatomy, Lorestan University of Medical Sciences, Faculty of Medicine, Khoram Abad, Iran.
出版信息
J Nephropathol. 2013 Jan;2(1):20-7. doi: 10.5812/nephropathol.9093. Epub 2013 Jan 1.
CONTEXT
Oxidative stress has crucial role in pathogenesis of diabetic nephropathy (DN). Despite satisfactory results from antioxidant therapy in rodent, antioxidant therapy showed conflicting results in combat with DN in diabetic patients.
EVIDENCE ACQUISITIONS
Directory of Open Access Journals (DOAJ), Google Scholar,Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched.
RESULTS
Treatment of DN in human are insufficient with rennin angiotensin system (RAS) blockers, so additional agent ought to combine with this management. Meanwhile based on DN pathogenesis and evidences in experimental and human researches, the antioxidants are the best candidate. New multi-property antioxidants may be improved human DN that show high power antioxidant capacity, long half-life time, high permeability to mitochondrion, improve body antioxidants enzymes activity and anti-inflammatory effects.
CONCLUSIONS
Based on this review and our studies on diabetic rats, rosmarinic acid a multi-property antioxidant may be useful in DN patients, but of course, needs to be proven in clinical trials studies.
背景
氧化应激在糖尿病肾病（DN）的发病机制中起关键作用。尽管抗氧化治疗在啮齿动物中取得了令人满意的结果，但在糖尿病患者中，抗氧化治疗在对抗DN方面显示出相互矛盾的结果。
证据收集
检索了开放获取期刊目录（DOAJ）、谷歌学术、PubMed（美国国立医学图书馆）、LISTA（EBSCO）和科学引文索引。
结果
肾素-血管紧张素系统（RAS）阻滞剂对人类DN的治疗并不充分，因此需要额外的药物与这种治疗方法相结合。同时，基于DN的发病机制以及实验和人体研究的证据，抗氧化剂是最佳选择。新型多特性抗氧化剂可能改善人类DN，其具有高抗氧化能力、长半衰期、对线粒体的高通透性、提高机体抗氧化酶活性和抗炎作用。
结论
基于本综述以及我们对糖尿病大鼠的研究，迷迭香酸这种多特性抗氧化剂可能对DN患者有用，但当然，这需要在临床试验中得到证实。
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