Rademaker M, Thomas R H, Provost G, Beacham J A, Cooke E D, Kirby J D
Department of Dermatology, St Bartholomew's Hospital, West Smithfield, London, UK.
Postgrad Med J. 1987 Aug;63(742):617-20. doi: 10.1136/pgmj.63.742.617.
Thirteen patients with Raynaud's phenomenon secondary to systemic sclerosis received three 8-hour infusions of a synthetic prostacyclin analogue (Iloprost) on consecutive days and were followed-up over a period of 10 weeks during the winter of 1985/86. Six weeks after infusion, digital peripheral vascular resistance had fallen (P less than 0.05) and dicrotic notch proportion of pulse amplitude increased (P less than 0.05). Digital blood flow and pulse amplitude (measured by photoplethymography) were also increased but did not reach statistical significance. The trend of improvement in these blood flow parameters was still evident after 10 weeks. The number of cutaneous lesions (digital ulcers, etc) fell from 26 lesions before infusion to only 7 lesions by the end of the study, confirming the subjective improvement reported by the patients.
13例继发于系统性硬化症的雷诺现象患者在连续3天接受了3次8小时的合成前列环素类似物（依洛前列素）静脉输注，并于1985/1986年冬季进行了为期10周的随访。输注6周后，指端外周血管阻力下降（P<0.05），脉搏波幅的重搏波切迹比例增加（P<0.05）。指端血流和脉搏波幅（通过光电容积描记法测量）也有所增加，但未达到统计学显著性。10周后这些血流参数的改善趋势仍然明显。皮肤病变（指端溃疡等）的数量从输注前的26处减少至研究结束时仅7处，证实了患者报告的主观改善情况。
