Cooke E D, Bowcock S A, Watkins C J, Rustin M H, Kirby J D
Angiology. 1985 Dec;36(12):867-71. doi: 10.1177/000331978503601205.
The beneficial effects of intra-arterial or intravenous infusion of the prostanoid products of anachridonic acid, PGE and prostacyclin (PGI2) are well documented. More recently an analogue of PGE2, (CL 115,347, American Cynamid Co.) has become available. This substance is absorbed transdermally from a patch placed on the skin. In a placebo-controlled trial the vasodilatory effect of single incremental dosage, 500 mcg, 1000 mcg and 1500 mcg, was measured in a temperature-/humidity controlled laboratory in normal subjects and in patients with primary and secondary Raynaud's phenomenon. The optimal dosage proved to be 1000 mcg; the effect may last for 84 hours; higher dosage may be associated with a "steal" phenomenon.
花生四烯酸的前列腺素产物、前列腺素E（PGE）和前列环素（PGI2）经动脉内或静脉内输注的有益效果已有充分记录。最近，一种PGE2类似物（CL 115,347，美国氰胺公司）已可供使用。该物质可从贴于皮肤上的贴剂经皮吸收。在一项安慰剂对照试验中，在温度和湿度受控的实验室里，对正常受试者以及原发性和继发性雷诺现象患者测量了单次递增剂量500微克、1000微克和1500微克的血管舒张作用。结果证明最佳剂量为1000微克；其效果可持续84小时；更高剂量可能会出现“窃血”现象。
