日本北部中老年男性牙齿数量与全因死亡率及特定病因死亡率的关联：岩手县肯科研究
Associations of number of teeth with risks for all-cause mortality and cause-specific mortality in middle-aged and elderly men in the northern part of Japan: the Iwate-KENCO study.
作者信息
Ando Ayumi, Tanno Kozo, Ohsawa Masaki, Onoda Toshiyuki, Sakata Kiyomi, Tanaka Fumitaka, Makita Shinji, Nakamura Motoyuki, Omama Shinichi, Ogasawara Kuniaki, Ishibashi Yasuhiro, Kuribayashi Toru, Koyama Tomiko, Itai Kazuyoshi, Ogawa Akira, Okayama Akira
机构信息
Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan.
出版信息
Community Dent Oral Epidemiol. 2014 Aug;42(4):358-65. doi: 10.1111/cdoe.12095. Epub 2014 Jan 29.
OBJECTIVES
The objective of this study was to determine the associations of number of teeth with all-cause mortality and cause-specific mortality among middle-aged and elderly Japanese men.
METHODS
A total of 7779 men aged 40-79 years who were free from cardiovascular disease (CVD) were followed up prospectively for 5.6 years. Participants were categorized into four groups (no teeth, 1-9 teeth, 10-19 teeth, and ≥20 teeth) by a self-administered questionnaire. Using Cox's proportional hazard model, multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality from all causes, CVD, cancer, and noncancer, non-CVD according to number of teeth were estimated with adjustments for age, body mass index, systolic blood pressure, total- and HDL-cholesterol, HbA1c, current smoking, current alcohol drinking, and low level of education.
RESULTS
The numbers (proportions) of participants with no teeth, 1-9 teeth, 10-19 teeth, and ≥20 teeth were 1613 (20.7%), 1650 (21.2%), 1721 (22.1%), and 2795 (35.9%), respectively. During follow-up, a total of 455 deaths (including 175 deaths from cancer, 98 deaths from CVD, and 130 deaths from noncancer, non-CVD) were recorded. In total participants, an inverse relationship between number of teeth and all-cause mortality was found (P for trend = 0.049). Among men aged 40-64 years, inverse relationships were also found in risks for mortality from all causes, CVD, and cancer: multivariate-adjusted HRs (95% CI) for all-cause mortality in men with no teeth, 1-9 teeth, and 10-19 teeth relative to men with ≥20 teeth were 2.75 (1.37-5.49), 1.89 (0.99-3.63), and 1.94 (1.09-3.43), respectively. However, there were no associations of number of teeth with all-cause mortality and cause-specific mortality among men aged 65-79 years.
CONCLUSIONS
The number of teeth is an important predictive factor for mortality among middle-aged Japanese men.
目的
本研究旨在确定日本中老年男性牙齿数量与全因死亡率及特定病因死亡率之间的关联。
方法
对7779名年龄在40 - 79岁且无心血管疾病（CVD）的男性进行了为期5.6年的前瞻性随访。通过自填问卷将参与者分为四组（无牙、1 - 9颗牙、10 - 19颗牙和≥20颗牙）。使用Cox比例风险模型，在对年龄、体重指数、收缩压、总胆固醇和高密度脂蛋白胆固醇、糖化血红蛋白、当前吸烟状况、当前饮酒情况以及低教育水平进行调整后，估计不同牙齿数量组的全因死亡率、CVD死亡率、癌症死亡率和非癌症、非CVD死亡率的多变量风险比（HRs）及95%置信区间（CIs）。
结果
无牙、1 - 9颗牙、10 - 19颗牙和≥20颗牙的参与者人数（比例）分别为1613人（20.7%）、1650人（21.2%）、1721人（22.1%）和2795人（35.9%）。随访期间，共记录了455例死亡（包括175例癌症死亡、98例CVD死亡和130例非癌症、非CVD死亡）。在所有参与者中，发现牙齿数量与全因死亡率呈负相关（趋势P = 0.049）。在40 - 64岁的男性中，全因死亡率、CVD死亡率和癌症死亡率风险也呈负相关：无牙、1 - 9颗牙和10 - 19颗牙的男性相对于≥20颗牙的男性，全因死亡率的多变量调整HRs（95% CI）分别为2.75（1.37 - 5.49）、1.89（0.99 - 3.63）和1.94（1.09 - 3.43）。然而，在65 - 79岁的男性中，牙齿数量与全因死亡率及特定病因死亡率之间无关联。
结论
牙齿数量是日本中年男性死亡率的一个重要预测因素。
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