Ellervik Christina, Kvetny Jan, Christensen Kaj Sparle, Vestergaard Mogens, Bech Per
Christina Ellervik, M.D., Chief Physician, Department of Clinical Biochemistry, Naestved University Hospital, Copenhagen University Hospital , and Associate Professor, Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Denmark.
Nord J Psychiatry. 2014 Oct;68(7):507-12. doi: 10.3109/08039488.2013.877074. Epub 2014 Jan 29.
The Danish General Suburban Population Study (GESUS), the objective of which is to facilitate epidemiological and genetic research, has included the Major Depression Inventory (MDI) and the WHO-Five Well-Being Index (WHO-5) among the medical health questionnaires. We were thus in a position to compare the 2-week prevalence of ICD-10 depression in the period from 2010 to 2012 with our previous Danish general population study from 2003, in which the MDI was also included.
The aim of our analysis was not only to evaluate the point prevalence of ICD-10 depression but also to describe the prevalence of antidepressants received by the respondents in the GESUS study and the correspondence to their subjective well-being on the WHO-5 questionnaire.
To evaluate the validity (scalability) of the MDI and the WHO-5 in the GESUS study we performed the non-parametric Mokken analysis. The scalability of the MDI and the WHO-5 was quite acceptable.
In total, 14,787 respondents were available from a response rate of 50%. The 2-week prevalence of ICD-10 depression was 2.3%, which is rather similar to the 2.8% in our 2003 study. The rate of people receiving antidepressants increased consistently with increasing severity of ICD-10 depression.
This study has confirmed that the use of the MDI to obtain an ICD-10 depression diagnosis gives rather conservative estimates of the 2-week prevalence of depression in the Danish general population. The prescription of antidepressants depends on the severity of the ICD-10 depression diagnosis.
丹麦郊区普通人群研究（GESUS）旨在促进流行病学和基因研究，在其医疗健康问卷中纳入了抑郁自评量表（MDI）和世界卫生组织五福健康指数（WHO-5）。因此，我们能够将2010年至2012年期间国际疾病分类第10版（ICD-10）抑郁症的两周患病率与我们2003年进行的丹麦普通人群研究进行比较，该研究中也纳入了MDI。
我们分析的目的不仅是评估ICD-10抑郁症的时点患病率，还在于描述GESUS研究中受访者接受抗抑郁药治疗的患病率，以及其与WHO-5问卷中主观幸福感的对应关系。
为评估GESUS研究中MDI和WHO-5的有效性（可扩展性），我们进行了非参数莫肯分析。MDI和WHO-5的可扩展性相当令人满意。
共有14,787名受访者参与，回复率为50%。ICD-10抑郁症的两周患病率为2.3%，与我们2003年研究中的2.8%相当接近。接受抗抑郁药治疗的比例随ICD-10抑郁症严重程度的增加而持续上升。
本研究证实，使用MDI获得ICD-10抑郁症诊断对丹麦普通人群抑郁症两周患病率的估计较为保守。抗抑郁药的处方取决于ICD-10抑郁症诊断的严重程度。
