通过神经调节蛋白在微血管内皮细胞与心肌细胞之间进行信号传导。
Signalling between microvascular endothelium and cardiomyocytes through neuregulin.
作者信息
Parodi Emily M, Kuhn Bernhard
机构信息
Harvard Medical School, Boston Children's Hospital, 300 Longwood Avenue, Enders Building, Room 1212, Brookline, MA 02115, USA.
出版信息
Cardiovasc Res. 2014 May 1;102(2):194-204. doi: 10.1093/cvr/cvu021. Epub 2014 Jan 29.
Abstract
Heterocellular communication in the heart is an important mechanism for matching circulatory demands with cardiac structure and function, and neuregulins (Nrgs) play an important role in transducing this signal between the hearts' vasculature and musculature. Here, we review the current knowledge regarding Nrgs, explaining their roles in transducing signals between the heart's microvasculature and cardiomyocytes. We highlight intriguing areas being investigated for developing new, Nrg-mediated strategies to heal the heart in acquired and congenital heart diseases, and note avenues for future research.
摘要
心脏中的异细胞通讯是使循环需求与心脏结构和功能相匹配的重要机制，而神经调节蛋白（Nrgs）在心脏血管系统和肌肉组织之间传递这一信号中发挥着重要作用。在此，我们综述了有关Nrgs的现有知识，阐释它们在心脏微血管和心肌细胞之间传递信号的作用。我们着重介绍了正在研究的、用于开发新型Nrg介导策略以治疗获得性和先天性心脏病的有趣领域，并指出了未来的研究方向。
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2
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3
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4
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