从人类内脏利什曼病合并HIV感染患者的口腔脱落细胞拭子样本中特异性非侵入性检测杜氏利什曼原虫。
Specific noninvasive detection of Leishmania donovani in desquamated buccal cell swab samples from human visceral Leishmaniasis-HIV coinfected patients.
作者信息
Das Sushmita, Halder Avishek, Rabidas Vidya Nand, Mandal Abhishek, Das Pradeep
机构信息
Department of Molecular Biology, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Patna, India.
出版信息
J Clin Microbiol. 2014 Apr;52(4):1238-41. doi: 10.1128/JCM.02819-13. Epub 2014 Jan 29.
Abstract
Diagnosis of human immunodeficiency virus (HIV) infection with visceral leishmaniasis (VL) coinfection is challenging. Specific diagnosis of VL in HIV-coinfected patients was evaluated by molecular methods in desquamated buccal swab samples, demonstrating 86.3% sensitivity and 98.3% specificity in controls. This test holds significant potential for development as a noninvasive diagnostic tool for VL in HIV-coinfected patients.
摘要
诊断人类免疫缺陷病毒（HIV）感染合并内脏利什曼病（VL）具有挑战性。通过分子方法对HIV合并感染患者的脱落口腔拭子样本进行VL特异性诊断评估，结果显示在对照组中灵敏度为86.3%，特异性为98.3%。该检测作为HIV合并感染患者VL的非侵入性诊断工具具有很大的开发潜力。
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