人体内脏利什曼病的非侵入性分子诊断。
Noninvasive molecular diagnosis of human visceral leishmaniasis.
机构信息
Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
出版信息
J Clin Microbiol. 2011 May;49(5):2003-5. doi: 10.1128/JCM.00130-11. Epub 2011 Mar 9.
Abstract
Previously developed methods for noninvasive PCR diagnosis of visceral leishmaniasis (VL) have significant limitations. Diagnosis of VL using PCR and buccal swabs was evaluated in 307 subjects, including 148 patients confirmed to have VL. This method is simple and well tolerated and has good potential for development, showing 83% sensitivity with 90.56% specificity in control groups.
摘要
先前开发的用于内脏利什曼病（VL）非侵入性 PCR 诊断的方法存在显著局限性。本研究评估了使用 PCR 和口腔拭子诊断 VL 的方法，共纳入 307 名受试者，包括 148 名经证实患有 VL 的患者。该方法简单且耐受性良好，具有良好的开发潜力，在对照组中的敏感性为 83%，特异性为 90.56%。
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