增强子 RNA：转录的新分子。
Enhancer RNAs: the new molecules of transcription.
机构信息
Wistar Institute, Philadelphia, PA 19104, USA.
Wistar Institute, Philadelphia, PA 19104, USA.
出版信息
Curr Opin Genet Dev. 2014 Apr;25:38-42. doi: 10.1016/j.gde.2013.11.017. Epub 2014 Jan 28.
Abstract
In the past few years, technological advances in nucleotide sequencing have culminated in a greater understanding of the complexity of the human transcriptome. Notably, the discovery that distal regulatory elements known as enhancers are transcribed and such enhancer-derived transcripts (eRNAs) serve a critical function in transcriptional activation has added a new dimension to transcriptional regulation. Here we review recent insights into the tissue-specific and temporal-specific gene regulation brought about by the discovery of eRNAs.
摘要
在过去的几年中，核苷酸测序技术的进步使得人们对人类转录组的复杂性有了更深入的了解。值得注意的是，人们发现了一种被称为增强子的远端调控元件可以被转录，而这些增强子衍生的转录本（eRNAs）在转录激活中起着关键作用，这为转录调控增添了一个新的维度。在这里，我们回顾了最近关于发现 eRNAs 带来的组织特异性和时间特异性基因调控的新见解。
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本文引用的文献
1
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Mol Cell. 2013 Sep 12;51(5):606-17. doi: 10.1016/j.molcel.2013.07.022. Epub 2013 Aug 29.
2
lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs.lncRNA 依赖的雄激素受体调控基因激活程序的机制。
Nature. 2013 Aug 29;500(7464):598-602. doi: 10.1038/nature12451. Epub 2013 Aug 14.
3
The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis.长非编码 RNA RMST 与 SOX2 相互作用，调节神经发生。
Mol Cell. 2013 Aug 8;51(3):349-59. doi: 10.1016/j.molcel.2013.07.017.
4
Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.在巨噬细胞激活过程中，增强子景观的重塑与增强子转录相偶联。
Mol Cell. 2013 Aug 8;51(3):310-25. doi: 10.1016/j.molcel.2013.07.010.
5
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.REV-ERBs 通过抑制增强子指导的转录来抑制巨噬细胞基因表达。
Nature. 2013 Jun 27;498(7455):511-5. doi: 10.1038/nature12209. Epub 2013 Jun 2.
6
Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation.增强子 RNA 在雌激素依赖性转录激活中的功能作用。
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7
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Cell. 2013 Jun 6;153(6):1281-95. doi: 10.1016/j.cell.2013.04.053. Epub 2013 May 23.
8
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10
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