新生儿的血红蛋白A/血红蛋白A2比值及其与胎儿成熟度的相关性。

The HbA/HbA2 ratio in newborns and its correlation with fetal maturity.

作者信息

Felicetti L, Novelletto A, Benincasa A, Terrenato L, Colombo B

出版信息

Br J Haematol. 1984 Mar;56(3):465-71. doi: 10.1111/j.1365-2141.1984.tb03976.x.

DOI:10.1111/j.1365-2141.1984.tb03976.x

PMID:6199038

Abstract

The relative amounts of HbF, HbA and HbA2 were determined in about 1000 newborns and their parents. In newborns the mean value of HbA2 was 0.27 +/- 0.02% and that of HbF 74.69 +/- 0.25%. The ratio HbA/HbA2 was estimated at different gestational ages and was found to range from 101 at 32 weeks gestation to 76 at 45 weeks, indicating that the relative amount of HbA2 increases with fetal maturation. The correlations between the levels of the different haemoglobins and various indexes of fetal maturation (gestational age, birth weight, crown-heel length and head circumference) are also given.

摘要

对约1000名新生儿及其父母的血红蛋白F（HbF）、血红蛋白A（HbA）和血红蛋白A2（HbA2）的相对含量进行了测定。新生儿中HbA2的平均值为0.27±0.02%，HbF的平均值为74.69±0.25%。在不同孕周估算了HbA/HbA2的比值，发现其范围从妊娠32周时的101到45周时的76，这表明HbA2的相对含量随着胎儿成熟而增加。还给出了不同血红蛋白水平与胎儿成熟的各种指标（孕周、出生体重、顶臀长度和头围）之间的相关性。