Barth A, Klinger W
Institute of Pharmacology and Toxicology, Friedrich-Schiller-University Jena, GDR.
Exp Clin Endocrinol. 1987 Sep;90(2):190-8. doi: 10.1055/s-0029-1210689.
In male Wistar rats of different ages the influence of a three days pretreatment with triiodothyronine (T3, 100 micrograms/kg b.m.s.c.) or dexamethasone (0.4 mg/kg b.m.i.p.) on eosine accumulation of rat liver in vitro and biliary excretion of eosine in vivo was investigated. T3 stimulated the eosine accumulation in liver slices. This in vitro effect was not paralleled by higher serum elimination rates of eosine in vivo. Neither T3 nor dexamethasone could accelerate the maturation of the rate limiting excretion process for organic anions in developing rats.
在不同年龄的雄性Wistar大鼠中，研究了用三碘甲状腺原氨酸（T3，100微克/千克体重，皮下注射）或地塞米松（0.4毫克/千克体重，腹腔注射）进行三天预处理对大鼠肝脏体外嗜酸性粒细胞蓄积及体内嗜酸性粒细胞胆汁排泄的影响。T3刺激肝切片中嗜酸性粒细胞的蓄积。这种体外效应在体内并未伴随着更高的嗜酸性粒细胞血清清除率。T3和地塞米松均不能加速发育中大鼠有机阴离子限速排泄过程的成熟。
