Yang Aifang, Wang Bin, Zhu Guoxing, Jiao Zheng, Fang Youxin, Tang Fengmin, Ma Chunlai, Zhao Yue, Cheng Cai, Zhong Mingkang
Department of Pharmacy, HuaShan Hospital, Fudan University, Shanghai, China.
Department of Neurology, HuaShan Hospital, Fudan University, Shanghai, China.
Seizure. 2014 Apr;23(4):295-9. doi: 10.1016/j.seizure.2014.01.003. Epub 2014 Jan 9.
This study aimed to validate a Chinese version of the Morisky Medication Adherence Scale (MMAS-8) in patients with epilepsy. The relationships between adherence, seizure frequency, and adverse effects were assessed using this method.
Data from patients diagnosed with epilepsy at the Department of Neurology of Huashan Hospital were collected between January and June 2013. To validate the MMAS-8, internal consistency, test-retest reliability, and factor analysis were calculated. Relationships between adherence, seizure frequency, and adverse effects were assessed using Pearson's correlation.
One hundred and eleven patients were recruited. The MMAS-8 had moderate internal consistency (Cronbach's α=0.556) and good test-retest reliability (intraclass correlation coefficient=0.729). The MMAS-8 adherence rate was 79.2%. MMAS-8 adherence was negatively correlated with seizure frequency and adverse effects (r = -0.708, p<0.001; r = -0.484, p<0.001).
The MMAS-8 scale can be used as a tool to assess medication adherence in Chinese patients with epilepsy. Better seizure control and lower rates of adverse effects were significantly correlated with higher adherence scores.
本研究旨在验证中文版的莫里西药物依从性量表（MMAS - 8）在癫痫患者中的有效性。使用该方法评估依从性、癫痫发作频率和不良反应之间的关系。
收集2013年1月至6月期间在华山医院神经内科确诊为癫痫的患者的数据。为验证MMAS - 8，计算了内部一致性、重测信度和因子分析。使用Pearson相关性评估依从性、癫痫发作频率和不良反应之间的关系。
招募了111名患者。MMAS - 8具有中等内部一致性（Cronbach's α = 0.556）和良好的重测信度（组内相关系数 = 0.729）。MMAS - 8的依从率为79.2%。MMAS - 8依从性与癫痫发作频率和不良反应呈负相关（r = -0.708，p < 0.001；r = -0.484，p < 0.001）。
MMAS - 8量表可作为评估中国癫痫患者药物依从性的工具。更好的癫痫控制和更低的不良反应发生率与更高的依从性得分显著相关。
