复杂天然样品的通用定量 NMR 分析。
Universal quantitative NMR analysis of complex natural samples.
机构信息
UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, College of Pharmacy, 833 S. Wood Street, Chicago, IL, United States.
UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, College of Pharmacy, 833 S. Wood Street, Chicago, IL, United States.
出版信息
Curr Opin Biotechnol. 2014 Feb;25:51-9. doi: 10.1016/j.copbio.2013.08.004. Epub 2013 Sep 14.
Nuclear Magnetic Resonance (NMR) is a universal and quantitative analytical technique. Being a unique structural tool, NMR also competes with metrological techniques for purity determination and reference material analysis. In pharmaceutical research, applications of quantitative NMR (qNMR) cover mostly the identification and quantification of drug and biological metabolites. Offering an unbiased view of the sample composition, and the possibility to simultaneously quantify multiple compounds, qNMR has become the method of choice for metabolomic studies and quality control of complex natural samples such as foods, plants or herbal remedies, and biofluids. In this regard, NMR-based metabolomic studies, dedicated to both the characterization of herbal remedies and clinical diagnosis, have increased considerably.
核磁共振（NMR）是一种通用且定量的分析技术。作为一种独特的结构工具，NMR 还与计量技术竞争，用于纯度测定和参考物质分析。在药物研究中，定量核磁共振（qNMR）的应用主要涵盖药物和生物代谢物的鉴定和定量。qNMR 提供了对样品组成的无偏看法，并有可能同时定量多种化合物，因此已成为代谢组学研究和复杂天然样品（如食品、植物或草药制剂以及生物流体）质量控制的首选方法。在这方面，基于 NMR 的代谢组学研究，致力于草药制剂的表征和临床诊断，已经大大增加。
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