Grimal Quentin, Rohrbach Daniel, Grondin Julien, Barkmann Reinhard, Glüer Claus-C, Raum Kay, Laugier Pascal
Sorbonne Universités, UPMC Univ Paris 06, UMR 7623, LIP, F-75006, Paris, France; CNRS, UMR 7623, LIP, F-75006, Paris, France.
Julius Wolff Institute and Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Ultrasound Med Biol. 2014 May;40(5):1015-26. doi: 10.1016/j.ultrasmedbio.2013.11.010. Epub 2014 Jan 30.
Quantitative ultrasound assessment of the cortical compartment of the femur neck (FN) is investigated with the goal of achieving enhanced fracture risk prediction. Measurements at the FN are influenced by bone size, shape and material properties. The work described here was aimed at determining which FN material properties have a significant impact on ultrasound propagation around 0.5 MHz and assessing the relevancy of different models. A methodology for the modeling of ultrasound propagation in the FN, with a focus on the modeling of bone elastic properties based on scanning acoustic microscopy data, is introduced. It is found that the first-arriving ultrasound signal measured in through-transmission at the FN is not influenced by trabecular bone properties or by the heterogeneities of the cortical bone mineralized matrix. In contrast, the signal is sensitive to variations in cortical porosity, which can, to a certain extent, be accounted for by effective properties calculated with the Mori-Tanaka method.
为提高骨折风险预测能力，对股骨颈（FN）皮质骨部分进行了定量超声评估。股骨颈处的测量受骨大小、形状和材料特性影响。本文所述工作旨在确定哪些股骨颈材料特性对0.5MHz左右的超声传播有显著影响，并评估不同模型的相关性。介绍了一种用于模拟股骨颈超声传播的方法，重点是基于扫描声学显微镜数据对骨弹性特性进行建模。研究发现，在股骨颈处通过透射测量的首个到达超声信号不受小梁骨特性或皮质骨矿化基质不均匀性的影响。相比之下，该信号对皮质骨孔隙率的变化敏感，在一定程度上，可用Mori-Tanaka方法计算的有效特性来解释。
