Yamaguchi Seiji, Nath Shekhar, Matsushita Tomiharu, Kokubo Tadashi
Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan.
Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan.
Acta Biomater. 2014 May;10(5):2282-9. doi: 10.1016/j.actbio.2014.01.026. Epub 2014 Jan 30.
A nanostructured sodium hydrogen titanate layer ∼1μm in thickness was initially produced on the surface of titanium metal (Ti) by soaking in NaOH solution. When the metal was subsequently soaked in a mixed solution of CaCl2 and SrCl2, its Na ions were replaced with Ca and Sr ions in an Sr/Ca ratio in the range 0.18-1.62. The metal was then heat-treated at 600°C to form strontium-containing calcium titanate (SrCT) and rutile on its surface. The treated metal did not form apatite in a simulated body fluid (SBF) even after 7days. When the metal formed with SrCT was subsequently soaked in water at 80°C, the treated metal formed bone-like apatite on its surface within 1day in SBF since the Ca ions were partially replaced with H3O(+) ions. However, it released only 0.06ppm of Sr ions even after 7days in phosphate-buffered saline. When the metal was soaked after the heat treatment in 1M SrCl2 solution instead of water, the treated metal released 0.92ppm of Sr ions within 7days while maintaining its apatite-forming ability. The Ti formed with this kind of bioactive SrCT layer on its surface is expected to be highly useful for orthopedic and dental implants, since it should be able to promote bone growth by releasing Sr ions and tightly bond to the bone through the apatite formed on its surface.
通过将钛金属（Ti）浸泡在NaOH溶液中，最初在其表面制备了一层厚度约为1μm的纳米结构钛酸钠氢层。随后，当该金属浸泡在CaCl2和SrCl2的混合溶液中时，其Na离子被Sr/Ca比在0.18 - 1.62范围内的Ca和Sr离子取代。然后将该金属在600°C下进行热处理，以在其表面形成含锶钛酸钙（SrCT）和金红石。即使经过7天，处理后的金属在模拟体液（SBF）中也未形成磷灰石。当形成SrCT的金属随后在80°C的水中浸泡时，由于Ca离子部分被H3O(+)离子取代，处理后的金属在SBF中1天内在其表面形成了骨样磷灰石。然而，即使在磷酸盐缓冲盐水中浸泡7天后，它也仅释放0.06ppm的Sr离子。当热处理后的金属浸泡在1M SrCl2溶液而非水中时，处理后的金属在7天内释放0.92ppm的Sr离子，同时保持其磷灰石形成能力。表面形成这种生物活性SrCT层的Ti有望在骨科和牙科植入物中非常有用，因为它应该能够通过释放Sr离子促进骨生长，并通过其表面形成的磷灰石与骨紧密结合。
