Szabo T, Blähser S, Denizot J P, Véron-Ravaille M
Département de Neurophysiologie Sensorielle, C.N.R.S., Gif sur Yvette, France.
Neurosci Lett. 1987 Oct 29;81(3):245-9. doi: 10.1016/0304-3940(87)90390-9.
Substance P has been proposed as a candidate neurotransmitter or neuromodulator in the nociceptive system. Using a light microscopial immunohistochemical peroxidase-anti-peroxidase technique we have detected high substance P-like immunoreactivity (SPLI) in several types of sensory organs of 4 species of gymnotiform teleost fish: olfactory epithelium, vestibular, lateral line and electrosensory organs. The olfactory nerve and its endings within the olfactory bulb and the telencephalon were also strongly labelled. At these sites no SPLI was revealed in other teleosts (Carassius auratus, Gnathonemus petersii). The findings suggest that substance P may be involved in neurotransmission or neuromodulation in these specific sensory systems of these species.
P物质已被提出作为伤害感受系统中的一种候选神经递质或神经调质。我们使用光学显微镜免疫组织化学过氧化物酶-抗过氧化物酶技术，在4种裸背电鳗目硬骨鱼的几种感觉器官中检测到了高P物质样免疫反应性（SPLI）：嗅觉上皮、前庭、侧线和电感觉器官。嗅神经及其在嗅球和端脑内的末梢也被强烈标记。在这些部位，其他硬骨鱼（鲫鱼、彼得氏裸臀鱼）未显示出SPLI。这些发现表明，P物质可能参与了这些物种这些特定感觉系统中的神经传递或神经调节。
