Yoshimatsu Kumiko, Arikawa Jiro
Department of Microbiology, Graduate School of Medicine, Hokkaido University, Kita-ku, Kita-15, Nishi-7, Sapporo 060-8638, Japan.
Department of Microbiology, Graduate School of Medicine, Hokkaido University, Kita-ku, Kita-15, Nishi-7, Sapporo 060-8638, Japan.
Virus Res. 2014 Jul 17;187:77-83. doi: 10.1016/j.virusres.2013.12.040. Epub 2014 Jan 31.
Hantaviruses are causative agents of two rodent-borne zoonoses, hemorrhagic fever with renal syndrome (HFRS) and nephropathia epidemica (NE) in the Old World and hantavirus pulmonary syndrome (HPS) in the New World. Serological examinations to detect hantavirus antibodies have been most widely used for surveillance among humans and rodent reservoirs. Here, we will review antigenic structure of nucleocapsid (N) protein of hantaviruses and application of recombinant N protein as diagnostic antigen for screening and serotyping.
汉坦病毒是两种由啮齿动物传播的人畜共患病的病原体，在旧世界为肾综合征出血热（HFRS）和流行性肾病（NE），在新世界为汉坦病毒肺综合征（HPS）。检测汉坦病毒抗体的血清学检查在人类和啮齿动物宿主监测中应用最为广泛。在此，我们将综述汉坦病毒核衣壳（N）蛋白的抗原结构以及重组N蛋白作为诊断抗原用于筛查和血清分型的应用。
