慢性疼痛中的脑脊液单胺代谢产物

CSF monoamine metabolites in chronic pain.

作者信息

France Randal D, Urban Bruno J, Pelton Susan, Kilts Clinton D, Hong Jau-Shyong, Nemeroff Charles B

机构信息

Department of Psychiatry, Duke University Medical Center, Durham, NCU.S.A. Department of Anesthesiology, Duke University Medical Center, Durham, NCU.S.A. Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Services, Durham, NCU.S.A.

出版信息

Pain. 1987 Nov;31(2):189-198. doi: 10.1016/0304-3959(87)90035-2.

DOI:10.1016/0304-3959(87)90035-2

PMID:2448727

Abstract

Metabolites of selected neurotransmitters (5-HIAA, HVA and DOPAC) and beta-endorphin were measured in the CSF of 39 chronic pain patients and compared to controls. Twelve of the pain patients also fulfilled criteria for major depression. The concentration of 5-HIAA was increased in female but not male pain patients; there was no significant difference in the CSF concentrations of HVA and DOPAC. The presence of depression did not influence the concentrations of neurotransmitters. No correlation was found between the concentrations of monoamine metabolites and beta-endorphin. However, there was a positive correlation between 5-HIAA and HVA in controls and chronic pain patients without depression but not in depressed patients. It is concluded: chronic pain states are associated with elevation of CSF 5-HIAA in female patients; depression abolishes a positive correlation between 5-HIAA and HVA.

摘要

在39名慢性疼痛患者的脑脊液中测量了所选神经递质（5-羟吲哚乙酸、高香草酸和3,4-二羟基苯乙酸）的代谢产物以及β-内啡肽，并与对照组进行了比较。其中12名疼痛患者还符合重度抑郁症的标准。女性疼痛患者脑脊液中5-羟吲哚乙酸的浓度升高，而男性患者则未升高；高香草酸和3,4-二羟基苯乙酸的脑脊液浓度无显著差异。抑郁症的存在并未影响神经递质的浓度。单胺代谢产物浓度与β-内啡肽之间未发现相关性。然而，在对照组和无抑郁症的慢性疼痛患者中，5-羟吲哚乙酸与高香草酸之间存在正相关，而在抑郁症患者中则不存在。结论：慢性疼痛状态与女性患者脑脊液中5-羟吲哚乙酸升高有关；抑郁症消除了5-羟吲哚乙酸与高香草酸之间的正相关。