Department of Oto-Rhino-Laryngology Surgery, Ren Ji Hospistal, School of Medicine, Shanghai Jiao Tong University, Building 10, No. 1630, DongFang Road, 200127, Shanghai, China.
Eur Arch Otorhinolaryngol. 2014 Jun;271(6):1667-72. doi: 10.1007/s00405-014-2896-7. Epub 2014 Feb 1.
Postoperative sore throat (POST) is one of the main postoperative complaints. This study was to evaluate the efficacy of budesonide inhalation suspension (BIS) in reducing the incidence and severity of POST. One hundred and twenty patients scheduled for thyroid surgery with general anesthesia were enrolled and randomized into three groups. Group A received 200 mcg BIS 10 min prior to the tracheal intubation and received the same treatment 6 and 24 h after extubation. Group B received 200 mcg BIS 6 and 24 h after extubation. Control group received the same scheduled treatment as Group A, but the BIS was replaced with 2 ml normal saline. The patients were evaluated for sore throat and hoarseness 1, 24 and 48 h after extubation. The status of laryngopharynx was also recorded. There was no statistically significant difference in the incidence of sore throat among three groups. However, hoarseness occurred significantly less frequently in Group A (P < 0.05). One hour after extubation, Group A exhibited significantly less severe sore throat and hoarseness compared to the other two groups (P < 0.05), which disappeared 24 h later. The mucositis scores of laryngopharynx at 1, 24 and 48 h post-extubation were significantly lower in Group A (P < 0.05). BIS can reduce the incidence and severity of the POST prophylactically.
术后咽喉痛（POST）是主要的术后主诉之一。本研究旨在评估布地奈德混悬液（BIS）降低 POST 发生率和严重程度的疗效。将 120 例拟行全身麻醉甲状腺手术的患者纳入并随机分为三组。A 组患者于气管插管前 10min 给予 200μg BIS，气管拔管后 6 和 24h 给予相同剂量的治疗。B 组患者在气管拔管后 6 和 24h 给予 200μg BIS。对照组患者给予与 A 组相同的计划治疗，但 BIS 被 2ml 生理盐水替代。患者在拔管后 1、24 和 48h 时评估咽喉痛和声音嘶哑情况，并记录咽喉部状况。三组患者的咽喉痛发生率无统计学差异。但 A 组的声音嘶哑发生率明显较低（P<0.05）。拔管后 1h，A 组的咽喉痛和声音嘶哑程度明显低于其他两组（P<0.05），24h 后消失。拔管后 1、24 和 48h，A 组的咽喉部黏膜炎症评分明显较低（P<0.05）。BIS 可预防性降低 POST 的发生率和严重程度。
