Pifko Elysha, Price Amanda, Sterner Sarah
Resident Physician (Pifko), Pediatric Emergency Medicine Fellow (Price), Pediatric Emergency Medicine Attending Physician (Sterner), Medical University of South Carolina, Charleston, SC.
Pediatr Emerg Care. 2014 Feb;30(2):120-4; quiz 125-7. doi: 10.1097/PEC.0000000000000079.
Infant botulism is caused by the ingestion of Clostridium botulinum spores and leads to a life-threatening descending motor weakness and flaccid paralysis in infant children. This disease presents with symptoms such as constipation, weakness, and hypotonia and can lead to respiratory failure. Botulism immune globulin (BIG) was created to treat this deadly disease and functions by neutralizing all systemically circulating botulism toxins. It is indicated in children with clinically diagnosed infant botulism, before diagnostic confirmation, and has been shown to lead to a significant reduction in intensive care unit and hospital stay for these patients. This review article discusses the epidemiology, clinical presentation, history of BIG, and indications for administration of BIG.
婴儿肉毒中毒是由于摄入肉毒梭菌孢子引起的，会导致婴幼儿出现危及生命的下行性运动无力和弛缓性麻痹。这种疾病表现为便秘、无力和肌张力减退等症状，并可能导致呼吸衰竭。肉毒中毒免疫球蛋白（BIG）被用于治疗这种致命疾病，其作用是中和所有全身循环的肉毒中毒毒素。它适用于临床诊断为婴儿肉毒中毒的儿童，在诊断确认之前使用，并且已证明可显著缩短这些患者在重症监护病房的住院时间和总住院时间。这篇综述文章讨论了肉毒中毒免疫球蛋白的流行病学、临床表现、历史以及给药指征。
