非癌性复杂疾病中的全局基因表达分布

Global gene expression distribution in non-cancerous complex diseases.

作者信息

Wu Yun, Jin Nana, Zhu Haiyang, Li Chunmiao, Liu Nannan, Huang Yan, Miao Zhengqiang, Bi Xiaoman, Wu Deng, Chen Xi, Xiao Yun, Hao Dapeng, Li Chuanxing, Gong Binsheng, Zhang Shaojun, Zhuang Liwei, Li Kongning, Wang Dong

机构信息

College of Bioinformatics Science and Technology, the Fourth Affiliated Hospital, Harbin Medical University, 157 Baojian Road, Harbin, China.

出版信息

Mol Biosyst. 2014 Apr;10(4):728-31. doi: 10.1039/c3mb70524b. Epub 2014 Jan 31.

DOI:10.1039/c3mb70524b

PMID:24488172

Abstract

For gene expression in non-cancerous complex diseases, we systemically evaluated the sensitivities of biological discoveries to violation of the common normalization assumption. Our results indicated that gene expression may be widely up-regulated in digestive system and musculoskeletal diseases. However, global signal intensities showed little difference in other four disease types.

摘要

对于非癌性复杂疾病中的基因表达，我们系统地评估了生物学发现对违反常见归一化假设的敏感性。我们的结果表明，基因表达可能在消化系统和肌肉骨骼疾病中广泛上调。然而，在其他四种疾病类型中，整体信号强度几乎没有差异。