Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084 (China).
Angew Chem Int Ed Engl. 2014 Mar 3;53(10):2607-10. doi: 10.1002/anie.201310715. Epub 2014 Feb 2.
In molecular self-assembly molecules form organized structures or patterns. The control of the self-assembly process is an important and challenging topic. Inspired by the cytoskeletal-membrane protein lipid bilayer system that determines the shape of eukaryotic cells, we developed a frame-guided assembly process as a general strategy to prepare heterovesicles with programmed geometry and dimensions. This method offers greater control over self-assembly which may benefit the understanding of the formation mechanism as well as the functions of the cell membrane.
在分子自组装中，分子形成有组织的结构或图案。控制自组装过程是一个重要且具有挑战性的课题。受细胞骨架-膜蛋白-脂双层系统决定真核细胞形状的启发，我们开发了一种框架引导组装过程作为一种通用策略，用于制备具有编程几何形状和尺寸的异质囊泡。这种方法提供了对自组装的更好控制，这可能有助于理解细胞膜的形成机制和功能。
