Tang M-C, Cheng L, Qiu L, Jia R-G, Sun R-Q, Wang X-P, Hu G-Y, Zhao Y
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Eur Rev Med Pharmacol Sci. 2014;18(2):160-4.
Nonalcoholic fatty liver disease (NAFLD) is a clinicopathologic syndrome of which the main feature is diffuse macrovesicular hepatic steatosis caused by deposition of excessive free fatty acid and triglyceride in liver parenchyma.
To observe the efficacy of Tiopronin in treatment of severe nonalcoholic fatty liver disease (NAFLD).
30 patients with severe NAFLD were treated with Tiopronin for 3 months. 30 healthy people were selected as control. The body mass index (BMI) and plasma levels of endotoxin (ET), leptin, IL-6 and IL-8 were measured before and after treatment.
The serum levels of ET, leptin, IL-6 and IL-8 in severe NAFLD group were significantly higher than those in control group (p < 0.05). After treatment with Tiopronin, these indexes were significantly lower than before (p < 0.05).
The intestinal endotoxemia (IETM) occurs in patients with severe NAFLD. Leptin, IL-6 and IL-8 play important roles in pathogenesis of NAFLD. Tiopronin can reduce the levels of ET, leptin, IL-6 and IL-8 for treatment of NAFLD.
非酒精性脂肪性肝病（NAFLD）是一种临床病理综合征，其主要特征是肝脏实质中过量游离脂肪酸和甘油三酯沉积导致的弥漫性大泡性肝脂肪变性。
观察硫普罗宁治疗重度非酒精性脂肪性肝病（NAFLD）的疗效。
30例重度NAFLD患者接受硫普罗宁治疗3个月。选取30名健康人作为对照。治疗前后测量体重指数（BMI）以及内毒素（ET）、瘦素、白细胞介素-6和白细胞介素-8的血浆水平。
重度NAFLD组的ET、瘦素、白细胞介素-6和白细胞介素-8血清水平显著高于对照组（p < 0.05）。硫普罗宁治疗后，这些指标显著低于治疗前（p < 0.05）。
重度NAFLD患者存在肠源性内毒素血症（IETM）。瘦素、白细胞介素-6和白细胞介素-8在NAFLD发病机制中起重要作用。硫普罗宁可降低ET、瘦素、白细胞介素-6和白细胞介素-8水平以治疗NAFLD。
