Distinguishing constitutional and acquired nonclonal aneuploidy.
作者信息
Heng Henry H
机构信息
Center for Molecular Medicine and Genetics and Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201.
出版信息
Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E972. doi: 10.1073/pnas.1323636111. Epub 2014 Jan 31.
Abstract
摘要
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Distinguishing constitutional and acquired nonclonal aneuploidy.区分体质性和后天性非克隆性非整倍体。
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Reply to Heng: Inborn aneuploidy and chromosomal instability.回复亨：先天性非整倍体与染色体不稳定性。
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Understanding aneuploidy in cancer through the lens of system inheritance, fuzzy inheritance and emergence of new genome systems.从系统遗传、模糊遗传以及新基因组系统的出现角度理解癌症中的非整倍体现象。
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Chromosome mis-segregation and cytokinesis failure in trisomic human cells.三体人类细胞中的染色体错分离和胞质分裂失败
Elife. 2015 May 5;4:e05068. doi: 10.7554/eLife.05068.
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Reply to Heng: Inborn aneuploidy and chromosomal instability.回复亨：先天性非整倍体与染色体不稳定性。
Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E973. doi: 10.1073/pnas.1323978111.
本文引用的文献
1
Whole chromosome gain does not in itself confer cancer-like chromosomal instability.整条染色体获得本身并不会导致类似癌症的染色体不稳定性。
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21119-23. doi: 10.1073/pnas.1311163110. Epub 2013 Dec 9.
2
Chromosomal instability (CIN): what it is and why it is crucial to cancer evolution.染色体不稳定性（CIN）：它是什么以及为何对癌症演变至关重要。
Cancer Metastasis Rev. 2013 Dec;32(3-4):325-40. doi: 10.1007/s10555-013-9427-7.
3
Stochastic cancer progression driven by non-clonal chromosome aberrations.由非克隆染色体畸变驱动的随机癌症进展。
J Cell Physiol. 2006 Aug;208(2):461-72. doi: 10.1002/jcp.20685.
4
Cancer progression by non-clonal chromosome aberrations.非克隆性染色体畸变导致的癌症进展
J Cell Biochem. 2006 Aug 15;98(6):1424-35. doi: 10.1002/jcb.20964.
5
The chromosomal basis of cancer.癌症的染色体基础。
Cell Oncol. 2005;27(5-6):293-318. doi: 10.1155/2005/951598.
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