Does aneuploidy destabilize karyotypes automatically?
作者信息
Duesberg Peter H
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
出版信息
Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E974. doi: 10.1073/pnas.1401413111. Epub 2014 Feb 25.
Abstract
摘要
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Does aneuploidy destabilize karyotypes automatically?非整倍体是否会自动使核型不稳定？
Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E974. doi: 10.1073/pnas.1401413111. Epub 2014 Feb 25.
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本文引用的文献
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Whole chromosome gain does not in itself confer cancer-like chromosomal instability.整条染色体获得本身并不会导致类似癌症的染色体不稳定性。
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21119-23. doi: 10.1073/pnas.1311163110. Epub 2013 Dec 9.
2
Sporadic aneuploidy in PHA-stimulated lymphocytes of trisomies 21, 18, and 13.21、18和13三体综合征患者PHA刺激淋巴细胞中的散发性非整倍体现象。
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Comprehensive measurement of chromosomal instability in cancer cells: combination of fluorescence in situ hybridization and cytokinesis-block micronucleus assay.癌细胞中染色体不稳定性的综合测量：荧光原位杂交与胞质分裂阻滞微核试验的联合应用
FASEB J. 2005 May;19(7):828-30. doi: 10.1096/fj.04-2276fje. Epub 2005 Mar 9.
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Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy.癌细胞中染色体结构的不稳定性会随着非整倍体程度呈指数级增加。
Cancer Genet Cytogenet. 2003 May;143(1):59-72. doi: 10.1016/s0165-4608(03)00003-7.
5
Genetic instability of cancer cells is proportional to their degree of aneuploidy.癌细胞的基因不稳定性与其非整倍体程度成正比。
Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13692-7. doi: 10.1073/pnas.95.23.13692.
6
A liveborn infant with complete triploidy (69,XXX).一名活产的完全三倍体婴儿（69,XXX）。
J Med Genet. 1969 Dec;6(4):413-21. doi: 10.1136/jmg.6.4.413.
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