Marine Biochemistry Laboratory, Department of Chemistry and Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea.
Marine Biochemistry Laboratory, Department of Chemistry and Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea ; Department of Chemistry, Pukyong National University, Daeyeon Campus, 599-1, Nam gu, Busan, 608-737, Republic of Korea.
Evid Based Complement Alternat Med. 2013;2013:572859. doi: 10.1155/2013/572859. Epub 2013 Dec 31.
The marine environment represents a relatively available source of functional ingredients that can be applied to various aspects of food processing, storage, and fortification. Moreover, numerous marine invertebrates based compounds have biological activities and also interfere with the pathogenesis of diseases. Isolated compounds from marine invertebrates have been shown to pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, acquired immunodeficiency syndrome (AIDS), osteoporosis, and so forth. Extensive research within the last decade has revealed that most chronic illnesses such as cancer, neurological diseases, diabetes, and autoimmune diseases exhibit dysregulation of multiple cell signaling pathways that have been linked to inflammation. On the basis of their bioactive properties, this review focuses on the potential use of marine invertebrate derived compounds on anti-inflammatory and some chronic diseases such as cardiovascular disease, osteoporosis, diabetes, HIV, and cancer.
海洋环境代表了一种相对可用的功能性成分来源,可以应用于食品加工、储存和强化的各个方面。此外,许多基于海洋无脊椎动物的化合物具有生物活性,并且还干扰疾病的发病机制。已经证明,从海洋无脊椎动物中分离出的化合物具有药理学活性,有助于生物活性化合物的发明和发现,主要是针对癌症、艾滋病(AIDS)、骨质疏松症等致命疾病。在过去十年中的广泛研究表明,大多数慢性疾病,如癌症、神经疾病、糖尿病和自身免疫性疾病,表现出多个细胞信号通路的失调,这些通路与炎症有关。基于它们的生物活性特性,本综述重点介绍了海洋无脊椎动物衍生化合物在抗炎和一些慢性疾病(如心血管疾病、骨质疏松症、糖尿病、HIV 和癌症)中的潜在用途。